The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025.
Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing to determine the biological consequences of putative AD risk genes in cell models. Researchers will also characterize enhancers and AD-associated variants for risk genes using induced pluripotent stem cell-derived brain cells and organoids. Subawards of $1.5M each to the University of Pennsylvania and Weill Cornell Medicine will support the generation and analysis of brain organoids edited to have gene variants linked to Alzheimer's and functional genomic studies to identify causal genetic variations affecting regulatory regions. Overall, the research aims to provide a comprehensive annotation of AD risk genes and variants influencing gene expression networks and cellular pathways related to Alzheimer's disease pathogenesis.
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