This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $2,288,327 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The research aims to better understand the intersection of polygenic risk factors, biological aging, and key molecular pathways that initiate and drive MCI, with the goal of...
The National Institute on Aging (NIA) awarded a $791,086 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the Northern California Institute for Research and Education, Inc. (NCIRE) to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes (non-ADNC), such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project...
This $3,281,385 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to the University of California, San Diego (UCSD) aims to examine the role of specific phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions in existing Alzheimer's disease clinical trial datasets. The project will leverage data from 14,602 participants across 30 years of clinical trials to analyze the interaction of...
This $622,401 project grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports a multi-year research effort at the University of Southern California to develop advanced artificial intelligence models for analyzing neuroimaging data and identifying modifiable lifestyle factors that influence the progression of Alzheimer's disease and related dementias (ADRD). The key objectives of the project are to: 1) use deep learning and event-based...
The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
This Project Grant award, with a total funding amount of $2,365,042, was provided by the National Institute on Aging under the Aging Research federal grant program (CFDA 93.866) to conduct a cross-national evaluation of the biological underpinnings of Alzheimer's disease and related dementias (ADRD) between the United States and India. The primary objective is to leverage harmonized data on neurodegenerative biomarkers, cognitive outcomes, and other physiological markers to better understand the...
This federal Project Grant award of $778,551 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a research project to estimate a novel probabilistic dementia classification for over 10 million Medicare beneficiaries aged 65 and older. The objective is to better understand diagnostic disparities in Alzheimer's disease and related dementias, particularly among racial/ethnic minority and underserved rural populations. The project will leverage linked Health and...
This federal Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 (Aging Research) supports research to investigate neural circuit dysfunction in the lateral entorhinal cortex (LEC) of an Alzheimer's disease (AD) mouse model. The $1,566,554 grant awarded to the University of California, Irvine aims to determine: 1) the cell types exhibiting activity dysfunction in the LEC, 2) whether LEC dopamine dysfunction causes memory impairment, and 3) if LEC...
This two-year $327,500 Project Grant award from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) aims to develop novel statistical methods and tree-based algorithms to identify high-risk biomarker subgroups for Alzheimer's disease (AD) progression. The project will leverage longitudinal biomarker and risk factor data from the Preclinical AD Consortium (PAC) to construct personalized classification and prediction models for onset of AD-related...