This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
This $222,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate whether increasing autophagy, a cellular process, can delay age-related phenotypes and cognitive decline associated with HIV infection. The grant will support experiments using HIV-infected mouse models to determine if disrupting the interaction between the proteins Beclin1 and Bcl-2 can reduce inflammation, oxidative stress, and synaptic dysfunction - key factors in the...
This three-year project grant from the National Institutes of Health's National Institute on Aging, titled "Aging Research" under the CFDA number 93.866, provides $1,797,870 to Stony Brook University to investigate the mechanisms by which aging impacts the risks of Alzheimer's and related dementias. Specifically, the awardee will test the hypothesis that age and neurodegenerative protein pathology synergize to activate retrotransposons and endogenous retroviruses, mobile genetic...
This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,550,462 to Georgetown University to conduct a 5-year study examining the impact of Alzheimer's disease risk genes, particularly APOE E4, on brain function in older Black/African Americans living with HIV. The study will enroll 120 HIV-positive participants and 80 demographically matched controls, and utilize a combination of neuropsychological tests, neuroimaging, biomarker...
This $383,750 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of Nebraska Medical Center (UNMC) to explore the molecular, neuro-immune and behavioral changes that occur during HIV-associated progressive aging using a long-term humanized mouse model. The goal is to determine how HIV latency and antiretroviral therapy (ART) contribute to premature aging, referred to as "LAAGING", and the associated...
This $794,341 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) is supporting research to investigate the role of cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease progression. The research project, led by the University of Illinois, aims to elucidate how viral and bacterial pathogens can initiate blood-brain barrier dysfunction and cellular senescence, which in turn promote neuroinflammation and Alzheimer's disease...