This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $749,030 to The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, to conduct research on the connection between calcium signaling and autophagy defects in Alzheimer's disease neurons. The key objectives are to understand the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease and evaluate the effects of clinically relevant compounds on rescuing these defects and providing synaptoprotective and neuroprotective effects. The award period runs from December 15, 2024 to November 30, 2029.
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