This three-year, $3,885,924 Project Grant from the National Institute on Aging will support research to define the effect of the CLU RS11136000 single nucleotide polymorphism on the risk of Alzheimer's disease, alone or in combination with APOE4. The grantee, Beckman Research Institute of the City of Hope, will derive astrocytes with different APOE/CLU genotypes and cellular aging status from human induced pluripotent stem cells or through direct reprogramming. Astrocyte-neuron and...
The University of Virginia (UVA) has been awarded a $444,125 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to investigate the impact of reduced phagocytosis (cell debris clearance) on Alzheimer's disease (AD) pathology. The project aims to test the hypothesis that decreased efferocytosis (clearance of apoptotic cells) can alleviate amyloid-beta induced pathology by enhancing debris processing and degradation in microglia. Specific...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) for $426,829 supports the development of a microphysiological system that models the brain-meninges-lymph node axis in both healthy and Alzheimer's disease conditions. The grant, awarded to Virginia Polytechnic Institute & State University, will integrate tissue-engineered models of the human brain, lymph node, and meninges into a microfluidic device to study the interactions between these...
The National Institute on Aging (NIA) awarded a $828,534 Cooperative Agreement under the Aging Research federal grant program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to conduct a molecular dissection of the neuronal-adaptive immune-genomic axis. The goal is to identify novel integrative factors contributing to Alzheimer's disease (AD) pathogenesis or to the protection of brain neurons in the aging process. The project will apply large-scale, innovative,...
The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
This Project Grant award, identified as R01AG083943, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The $771,518.10 award supports research conducted by Brown University to elucidate the role of the protein CHI3L1/YKL-40 in the pathogenesis of Alzheimer's disease (AD). The key objectives of this 5-year project are: 1) to define the signaling mechanism by which CHI3L1 governs neurodegeneration caused by glial cell activation, and 2) to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $759,095.00 to the Rector & Visitors of the University of Virginia (UVA) to develop and deploy a non-invasive, MR image-guided, focused ultrasound (FUS)-mediated gene delivery strategy to selectively target and modulate microglial responses in mouse models of Alzheimer's disease. The goal is to inhibit the progression of Alzheimer's-related disease by blocking the microglial SHIP-1...
This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
The National Institutes of Health's National Institute on Aging awarded a $4.7 million Project Grant to the University of California, Davis under the Aging Research program (CFDA 93.866) to investigate neuropathogenesis in the interoceptive-allostatic network as part of an animal model of early Alzheimer's disease pathogenesis. The grant will fund detailed neuroimaging and histological analyses of the brain network responsible for generating and regulating affect in rhesus monkeys administered...