The National Institute on Aging (NIA) awarded a $828,534 Cooperative Agreement under the Aging Research federal grant program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to conduct a molecular dissection of the neuronal-adaptive immune-genomic axis. The goal is to identify novel integrative factors contributing to Alzheimer's disease (AD) pathogenesis or to the protection of brain neurons in the aging process. The project will apply large-scale, innovative,...
This $759,095 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to develop a non-invasive, MR image-guided focused ultrasound (FUS) gene delivery strategy to selectively target and inhibit the microglial SHIP-1 protein in Alzheimer's disease (AD) mouse models. The goal is to enhance microglial amyloid-beta phagocytosis and restore neuronal health, with the potential to limit AD disease progression. The research will involve optimizing the...
This $682,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Roskamp Institute, Inc. will investigate the influence of microglial cell depletion and repopulation on aducanumab-induced amyloid-related imaging abnormalities (ARIA) and vascular lesions in APOE4 carriers with Alzheimer's disease (AD). The goal is to reveal whether activated microglia-mediated cerebrovascular inflammation contributes to APOE4-mediated ARIA events following aducanumab...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This $794,341 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) is supporting research to investigate the role of cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease progression. The research project, led by the University of Illinois, aims to elucidate how viral and bacterial pathogens can initiate blood-brain barrier dysfunction and cellular senescence, which in turn promote neuroinflammation and Alzheimer's disease...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $239,758 to Virginia Polytechnic Institute & State University (Virginia Tech) to develop a microphysiological system that models the interaction between the brain, meninges, and lymphatic system in Alzheimer's disease. The project aims to integrate tissue-engineered models of the human brain, lymph node, and meninges into a microfluidic device to study the impact of Alzheimer's disease on...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $745,092 to the University of Virginia to investigate the role of RNA modification in the pathogenesis of Alzheimer's disease and related tauopathies. The 5-year project aims to: Decode the epitranscriptomic profiles impacted by tau pathology using advanced sequencing techniques to improve understanding of Alzheimer's disease mechanisms at the epitranscriptomic level. Determine the...
The National Institute on Aging (NIA) awarded a $639,740 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Rector & Visitors of the University of Virginia (UVA) for the project "CD38, T CELLS AND POST VIRAL LUNG SEQUELAE DURING AGING". The research aims to explore the role of the CD38 enzyme in the development of chronic lung fibrosis following respiratory viral infections, including COVID-19, in older individuals. The project will investigate how...