The University of Virginia (UVA) has been awarded a $444,125 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to investigate the impact of reduced phagocytosis (cell debris clearance) on Alzheimer's disease (AD) pathology. The project aims to test the hypothesis that decreased efferocytosis (clearance of apoptotic cells) can alleviate amyloid-beta induced pathology by enhancing debris processing and degradation in microglia. Specific...
The National Institute on Aging (NIA) awarded a $506,451 Project Grant under CFDA 93.866, the Aging Research federal grant program, to 3P Biotechnologies, Inc. The goal of this 1-year award is to develop an effective targeted delivery system for small interfering RNA (siRNA) therapeutics to mitigate neuroinflammatory diseases, such as Alzheimer's disease (AD). The key products or services to be delivered include: Optimizing the delivery of siRNA against the inflammatory regulator NF-kB (siNF-kB)...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $640,000 to Northeastern University to develop and apply new intravital microscopy techniques to study the effects of gamma entrainment (GENUS) neuromodulation in Alzheimer's disease (AD) models. The project aims to gain a deeper understanding of how GENUS influences cerebral energy metabolism and microvascular hemodynamics in the living brain at cellular resolution. The advanced...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
The National Institute on Aging (NIA) awarded a $613,571 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Chicago to develop in vivo production of chimeric antigen receptor (CAR)-modified microglia for treating Alzheimer's disease. The project aims to use blood-brain barrier crossing lipid nanoparticles to deliver mRNA encoding anti-amyloid-beta CAR constructs and interleukin-10 (IL-10) to induce an anti-inflammatory microglial response and...
This Project Grant award, with a total funding amount of $4,619,796.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant was awarded to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization located in Augusta, Georgia. The purpose of this grant is to investigate the use of noninvasive pulsed laser therapy as a potential therapeutic approach for brain protection in...
This $1,758,779 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the Winifred Masterson Burke Medical Research Institute to assess neuronal vulnerability in the entorhinal cortex due to Alzheimer's disease pathology. The key objectives are to determine whether hyperexcitability in Alzheimer's disease is caused by dysfunction of excitatory or inhibitory neurons in the entorhinal cortex, and to modulate neuronal activities to...
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
This $498,748 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research program) will fund research at the University of Massachusetts Medical School to elucidate the mechanisms by which the MS4A gene family regulates neurodegeneration in Alzheimer's disease and related disorders. The key objectives of this one-year grant are to: 1) determine the effects of deleting individual or multiple MS4A gene family members on neurodegenerative phenotypes in mouse...
The National Institute on Aging (NIA) awarded a $759,095 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the Rector & Visitors of the University of Virginia (UVA). The grant, which runs from May 15, 2025 to February 28, 2030, aims to develop and deploy MR image-guided focused ultrasound (FUS) technology to selectively target and inhibit the SHIP-1 gene in microglia, in order to improve amyloid-beta phagocytosis and restore neuronal health in Alzheimer's disease mouse models. The research project involves two specific aims: 1) developing a non-invasive, MR image-guided, FUS-mediated gene delivery strategy to efficiently transfect microglia, and 2) testing the therapeutic potential of this approach to reduce Alzheimer's-related pathologies and cognitive decline in multiple mouse models of the disease.