Project Grant RF1AG077484

Award Date 6/1/22
Completion Date 5/31/25
Dollars Obligated $4M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Texas, USA
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This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $1,100,000 in funding to the University of Texas Medical Branch at Galveston to support research into the mechanisms of pathological tau spreading in Alzheimer's disease. The project aims to determine how amyloid-beta oligomers modulate the binding and internalization of toxic tau oligomers to vulnerable synapses, which is a key component of the trans-synaptic spread of tau...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $431,750 will support the delivery of a novel immuno-gene therapy for treating tauopathy, a group of neurodegenerative conditions including Alzheimer's disease. The award will fund the development and testing of a recombinant adeno-associated virus (rAAV) expressing a single-chain fragment variable (scFv) antibody targeting oligomeric tau, a toxic tau species believed to be a key...
The National Institute on Aging (NIA) awarded a $1,698,335 Project Grant (CFDA 93.866 - Aging Research) to The Washington University to develop self-assembling peptide nanofiber vaccines targeting amyloid-beta and tau proteins for the treatment of neurodegenerative disorders like Alzheimer's disease and frontotemporal dementia. The key products and services to be delivered under this 5-year grant include: 1) assessing the toxicity and seeding capacity of the peptide nanofibers bearing...
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