This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The project aims to substantially expand understanding of protein dysfunctions in AD by applying state-of-the-art proteomic methods paired with proteogenomics across multiple brain regions, AD stages,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,250 to the University of California, San Diego (UCSD) to develop new tools for imaging the tau protein and its phase transitions in living cells. The research aims to map and measure tau in its soluble, liquid-liquid phase separation, and liquid-solid phase separation forms, which is a critical limitation in the field. The project will leverage a peptide-based probe and...
The National Institute on Aging (NIA) awarded a $1,147,300 Project Grant (CFDA 93.866 - Aging Research) to Wayne State University for a project titled "Local Protein Synthesis in Tau Pathology Neurodegeneration". The award period runs from Sep 1, 2024 to Jun 30, 2029. The project aims to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. The researchers will...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $119,071.00 to The Regents of the University of California, San Francisco (UCSF) from September 1, 2024 to August 31, 2026. The grant aims to create innovative computational tools to rebuild Tau amyloid epitopes observed in Frontotemporal Dementia (FTD) patients and validate them in situ. The designed proteins will then be utilized to investigate how the Tau amyloid epitopes interact with...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to discover and characterize novel tau proteoforms in blood that can differentiate Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) from healthy controls. The $3,687,575 award to the Trustees of Indiana University, Indianapolis, will leverage samples from completed clinical trials of tau immunotherapies to overcome sensitivity limitations and identify potential biomarkers for...
This Project Grant award of $1,698,335.00 from the National Institute on Aging (part of the Aging Research program, CFDA 93.866) supports the development and preclinical testing of self-adjuvanting peptide nanofiber (PNF) vaccines targeting amyloid-beta and tau proteins for Alzheimer's disease and frontotemporal dementia. The grant aims to: 1) assess the toxicity and seeding capacity of PNFs bearing these epitopes, 2) characterize the antibody responses to AB and tau PNF vaccines, and 3) develop...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in Alzheimer's disease and related dementias. The key focus areas include: Defining the effects of tau post-translational modifications on tau function and pathology. This will evaluate how modifications like phosphorylation, acetylation, and cross-linking impact the exposure of tau's regulatory...
This Project Grant award, with a total funding amount of $431,750, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award is for the development and evaluation of a novel immuno-gene therapy approach using a single-chain fragment variable (scFv) derived from an anti-tau oligomeric complex 1 (TOC1) antibody. The key objectives are to: 1) generate and validate the TOC1-scFv-HaloTag-Proteasome Degradation Signal (PDS)...
This Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive research project entitled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics". The research, conducted by The Regents of the University of California, San Francisco, aims to systematically elucidate the molecular and cellular mechanisms by which pathological tau drives neurodegeneration in Alzheimer's disease...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...