Project Grant R03AG088929

Award Date 8/15/24
Completion Date 7/31/26
Dollars Obligated $320K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Galveston, TX 77555, USA
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This Project Grant award of $310,000 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The two-fold goals of the project are: 1) to identify APA genes and pathways associated with AD pathology by analyzing existing single-nucleus RNA sequencing...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to elucidate the role of RNA modification in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The $745,092 award to the University of Virginia will fund a 5-year study to: 1) Decode the epitranscriptomic (RNA modification) profiles impacted by tau pathology in AD; 2) Determine the role of RNA methylation in AD pathogenesis using 3D neuron-glial brain assembloids;...
The National Institutes of Health (NIH) National Institute on Aging (NIA) awarded a $3,537,652 project grant (CFDA 93.866 - Aging Research) to the HudsonAlpha Institute for Biotechnology in Huntsville, AL. The funding will support a 5-year research project to comprehensively identify transcriptional regulators that control expression of the MAPT gene, which encodes the tau protein associated with neurodegenerative diseases. The key objectives are to: 1) Use CRISPR screening to identify...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $1,100,000 in funding to the University of Texas Medical Branch at Galveston to support research into the mechanisms of pathological tau spreading in Alzheimer's disease. The project aims to determine how amyloid-beta oligomers modulate the binding and internalization of toxic tau oligomers to vulnerable synapses, which is a key component of the trans-synaptic spread of tau...
This federal Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $816,661 to The Regents of the University of California, San Francisco to conduct research on the molecular and cellular mechanisms by which pathological tau protein drives neurodegeneration in Alzheimer's disease (AD) and related tauopathies. The project will leverage expertise in mass spectrometry-based proteomics and functional genomics to comprehensively map the impact of...
The University of California, Irvine was awarded a $773,816 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct cell-type-specific and spatial proteogenomics analysis of aberrant RNA splicing and misfolded proteins in Alzheimer's-related tauopathies. The research aims to generate single-cell spatial proteo-transcriptomics maps to molecularly characterize aberrant RNA splicing and abnormal protein products in specific brain cell types in mouse models and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in neurodegenerative diseases like Alzheimer's. The central hypothesis is that pathogenic forms of tau represent misregulation of normal tau functions as a scaffold for signaling pathways. The 2-year project aims to define the effects of tau post-translational modifications on tau function and...
The National Institute on Aging (NIA) awarded a $146,922 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to The Johns Hopkins University to investigate the role of the protein GDE2 in regulating the post-translational modifications of the tau protein, which is associated with the development of Alzheimer's disease and related dementias. The project aims to utilize mouse models to examine how the loss of GDE2 affects the onset and progression of neurodegeneration in the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $717,709 to Weill Medical College of Cornell University to conduct research on the mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research aims to discover AD-relevant cellular machinery and pathways involved in tau propagation using...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $2,836,419 to the Seattle Institute for Biomedical and Clinical Research to investigate how the SUT-6/NIPP1 protein regulates pathological tau in Alzheimer's disease and other neurodegenerative "tauopathies." The 5-year research project aims to: 1) define the functions of SUT-6/NIPP1 important for suppressing tau toxicity, 2) identify downstream mediators of SUT-6/NIPP1's...

The National Institute on Aging (NIA) awarded a $320,000 Project Grant (CFDA 93.866) to the University of Texas Medical Branch at Galveston (UTMB) to study the role of alternative polyadenylation (APA) regulation in Alzheimer's disease (AD). The project aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins, which are implicated in AD pathogenesis. Using the innovative Poly(A)-ClickSeq (PAC-Seq) technology, the researchers will identify and compare mRNA isoform libraries from mouse primary hippocampal neurons expressing human wild-type tau and pathogenic mutant tau. Additionally, the study will pinpoint changes in tau oligomer-modulated mRNA isoform levels and expression through biochemical and cellular assays. By connecting APA with tau pathology, this research seeks to advance the understanding of how pathological tau affects RNA processing and gene expression in AD and related dementias.

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