Project Grant RD830766010

Federal Project Grant Summary Midwestern University received a $521,992 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 1, 2025, with completion targeted for August 31, 2028. This award funds research investigating how phthalate exposure during critical developmental windows disrupts spermatogenesis through disruption of Liver Receptor Homolog-1 (LRH1) signaling in Sertoli cells. The...

Federal Grant Award Summary Wayne State University received a $143,331 Project Grant from the National Institute of Environmental Health Sciences under the Environmental Health program (CFDA 93.113), awarded September 1, 2025, with completion targeted for March 31, 2026. The grant supports research investigating the molecular mechanisms by which per- and polyfluoroalkyl substances (PFAS) exposure affects male reproductive health, specifically examining impacts on spermatogenesis and sperm...

Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded The Washington University a Project Grant of $419,676 (obligated April 3, 2026) under the Environmental Health program (CFDA 93.113) to develop an advanced in vitro screening system for identifying genetic regulators of genital development and urethral closure. The research addresses the significant public health concern of hypospadias and other male reproductive abnormalities, which...

The National Institute of Child Health and Human Development (NICHD) awarded a $160,500 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Baylor College of Medicine. The grant will support research investigating the mechanisms for reduced sex steroid hormone synthesis in male offspring born to mothers fed a low-protein diet during pregnancy. The researchers will use a previously developed rat model of lean type 2 diabetes to study how...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $421,047 to the University of Toledo to study the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders. The key objectives are to investigate how developmental exposure to the pyrethroid pesticide deltamethrin interacts with a genetic mutation in the SHANK3 gene, which is associated with...

The National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) awarded a $1,999,075 Project Grant (CFDA 93.113 Environmental Health) to The Feinstein Institutes for Medical Research on September 1, 2023. The purpose of this 3-year grant is to investigate phthalate exposure and its mechanisms of action in the neonatal intensive care unit (NICU) environment. Specifically, the project aims to: 1) determine the pharmacokinetic profile of common phthalate...

Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of Arizona a $466,470 Project Grant on June 24, 2025, under the Environmental Health program (CFDA 93.113) to investigate the mechanisms by which phthalate exposure impacts female reproductive health and metabolic function. The research will be conducted through March 31, 2030, at the University of Arizona's Tucson, Arizona facility. The project utilizes a...

Federal Project Grant Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $425,628 project grant to the Regents of the University of California at Riverside on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a two-year research initiative (through July 31, 2027) investigating the molecular mechanisms by which mutations in the Fragile X Messenger Ribonuclein 1...

Federal Project Grant Award Summary The University of California, Davis received a $128,898 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion scheduled for July 31, 2027. This award funds research investigating the three-dimensional (3D) genome-based transcriptional program governing male germline differentiation during...

Grant Award Summary Duke University received a $214,916 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective May 1, 2025, through April 30, 2027. This K99/R00 award funds research to elucidate the mechanisms by which fetal male germ cells repair double strand breaks (DSBs) in DNA and to determine the importance of this repair process in spermatogonial stem cell...