Project Grant R21ES036352

Award Date 8/14/24
Completion Date 7/31/26
Dollars Obligated $421K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Toledo, OH 43614, USA
Similar Awards
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, will fund research to investigate the potential impacts of developmental exposure to pyrethroid pesticides on neurodevelopmental disorders (NDDs) using the prairie vole as an animal model. The $605,550 award, effective May 1, 2025 through February 28, 2030, will support the University of Toledo in conducting a comprehensive...
This federal Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) provides $157,500 to the Regents of the University of California at Riverside to pilot studies on the potential link between prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and autism spectrum disorder (ASD) risk. The research aims to examine how PFAS exposure during development may interact with genetic factors to influence fetal neurodevelopment and...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $159,200.00 to the University of California, San Diego (UCSD) to conduct research on the role of oxidation-reduction (redox) signaling in normal neurodevelopment and the sensitivity of developing neurons to environmental exposures that can induce oxidative stress. The research aims to characterize redox signaling during...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, is providing $728,408 to investigate genetic factors that influence susceptibility to pesticide-induced Parkinson's disease. The research aims to biologically validate novel candidate gene variants identified through prior epidemiological studies. The project involves two complementary research approaches: 1) evaluating the effects...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $164,561.00 to the University of California, Davis (UC Davis) to study the potential mediating role of cytokines and DNA methylation in the association between prenatal exposure to endocrine disrupting chemicals (EDCs) and the development of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in children. The research aims to:...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $251,250 to The Feinstein Institutes for Medical Research to study sex-dependent dysregulation of parvalbumin interneurons as a pathway to autism spectrum disorder (ASD). The key objectives are to: 1) Determine if the reduction in parvalbumin-expressing interneurons observed in male mice exposed in utero to anti-CASPR2 antibodies is associated with...
The National Institute of Mental Health (NIMH) awarded a $437,250 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh to study the role of local interneurons in early cortical dysfunction in Shank3 knockout mice, a model of autism spectrum disorder (ASD). The grant will fund research using whole-cell electrophysiology and 2-photon microscopy to characterize the physiological properties of Shank3 knockout cortical parvalbumin and somatostatin-positive...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $187,431 to the University of North Carolina at Chapel Hill to determine whether early life sleep disruption interacts with distinct genetic vulnerabilities associated with autism spectrum disorder (ASD). The key objectives are to establish if early life sleep disruption is a risk factor contributing to ASD susceptibility by interacting with...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $504,283 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Icahn School of Medicine at Mount Sinai. The grant will fund a study examining the epidemiology and risk factors for autism spectrum disorder (ASD) in children born preterm, and determine if the genetic architecture of ASD differs between preterm and term-born children. The study will create a prospective...
This $688,904 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate the mechanisms linking developmental manganese (Mn) exposure, dopamine dysregulation, and the increased frequency of ADHD diagnoses. The research, conducted by Vanderbilt University Medical Center (VUMC) and sub-awardees Purdue University and Vanderbilt University, aims to deepen the understanding of...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $421,047 to the University of Toledo to study the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders.

The key objectives are to investigate how developmental exposure to the pyrethroid pesticide deltamethrin interacts with a genetic mutation in the SHANK3 gene, which is associated with autism, using the prairie vole as an animal model. The researchers will assess behavioral deficits in social interaction, communication, cognition, and repetitive behaviors in the offspring, as well as underlying biological changes in the brain. This research aims to elucidate how combined genetic and environmental risk factors contribute to the development of autism and other neurodevelopmental disorders, providing a foundation for future studies on multi-hit models of disease risk.

Generated 7/1/25, 1:50 AM