The National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS) awarded a $1,999,075 Project Grant (CFDA 93.113 Environmental Health) to The Feinstein Institutes for Medical Research on September 1, 2023. The purpose of this 3-year grant is to investigate phthalate exposure and its mechanisms of action in the neonatal intensive care unit (NICU) environment.
Specifically, the project aims to: 1) determine the pharmacokinetic profile of common phthalate compounds in preterm infants; 2) test common respiratory circuits used in the NICU to quantify phthalate exposure; and 3) use an animal model to examine the effects of phthalate inhalation on the development of chronic lung disease in premature infants. This research is intended to provide actionable data to improve NICU practices and inform future clinical investigations on the impacts of early-life phthalate exposure in preterm infants.
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