Project Grant R21ES038435
- Federal Project Grant Summary Midwestern University received a $521,992 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 1, 2025, with completion targeted for August 31, 2028. This award funds research investigating how phthalate exposure during critical developmental windows disrupts spermatogenesis through disruption of Liver Receptor Homolog-1 (LRH1) signaling in Sertoli cells. The...
- Federal Grant Award Summary Wayne State University received a $143,331 Project Grant from the National Institute of Environmental Health Sciences under the Environmental Health program (CFDA 93.113), awarded September 1, 2025, with completion targeted for March 31, 2026. The grant supports research investigating the molecular mechanisms by which per- and polyfluoroalkyl substances (PFAS) exposure affects male reproductive health, specifically examining impacts on spermatogenesis and sperm...
- Federal Grant Award Summary Bioprinting Laboratories Inc. received a $306,872 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded July 8, 2025, with completion targeted for October 31, 2026. The company is developing a high-throughput screening platform for assessing developmental neurotoxicity (DNT) in commercially used chemicals. The primary deliverable is an engineered system combining genetically...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Johns Hopkins University a $155,000 Project Grant on August 22, 2025, through the Environmental Health program (CFDA 93.113) to support research infrastructure and tool development for the Caenorhabditis Natural Diversity Resource (CaeDR). The grant funds Dr. Michael Sauria, a Research Software Engineer (RSE) in the Andersen Lab, to oversee critical computational and technical improvements to...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of North Carolina at Chapel Hill a $249,000 Project Grant effective September 12, 2025, through August 31, 2028, under the Environmental Health program (CFDA 93.113). This research initiative investigates the associations between prenatal exposure to phthalates and phthalate alternatives—ubiquitous endocrine-disrupting chemicals—and cardiometabolic development in fetuses and...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113) awarded $249,000 to the University of North Carolina at Chapel Hill on August 13, 2025, for a research project extending through July 31, 2028. This Project Grant supports longitudinal research characterizing the early life chemical exposome and its impact on structural and functional brain development in children from birth through age five. The research...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $248,994 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through July 3, 2028. This award supports investigator-initiated research to elucidate the mechanisms of de novo germline histone mutations underlying developmental disorders. The project integrates biochemical and genomic...
- Federal Grant Award Summary The University of Missouri System received a $709,369 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded February 1, 2026, with completion targeted for November 30, 2030. This research initiative investigates the role of the FOXL2 gene in urethra closure and hypospadias prevention, addressing a significant gap in...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) under its Environmental Health program (CFDA 93.113) awarded The Washington University in St. Louis a $1,575,500 Project Grant effective September 26, 2025, through June 30, 2030. This research initiative investigates the associations between prenatal and early childhood exposure to flame retardant chemicals—specifically polybrominated diphenyl ethers (PBDEs) and organophosphate esters...
- Federal Grant Award Summary The University of Illinois received a $2.74 million Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 15, 2025, with a completion date of September 14, 2029. This research initiative investigates the impacts of phthalate exposure on the development of social behavior circuits in the brain. The project will deliver mechanistic research examining how developmental...
The National Institute of Environmental Health Sciences (NIEHS) awarded The Washington University a Project Grant of $419,676 (obligated April 3, 2026) under the Environmental Health program (CFDA 93.113) to develop an advanced in vitro screening system for identifying genetic regulators of genital development and urethral closure. The research addresses the significant public health concern of hypospadias and other male reproductive abnormalities, which have doubled in incidence over the past 50 years and are suspected to be influenced by fetal exposure to endocrine disruptors. The funded research will produce refined high-throughput screening methodologies utilizing two purified genital tract mesenchymal cell populations to evaluate transcription factors downstream of androgen receptor signaling that govern genital masculinization and lower urinary tract development. The project will deliver two primary research outputs over the two-year performance period (April 3, 2026 – April 2, 2028): In Aim I, the development of purified mesenchymal cell populations isolated from developing genital tract tissue using tissue-specific mouse Cre lines, with characterization of their cellular responses to androgen stimulation; and In Aim II, execution of a proof-of-concept screening analysis to identify transcription factors governing cellular proliferation and migration. These deliverables are designed to accelerate the discovery of master regulators of urethral closure and advance understanding of the genetic pathways underlying genital development, ultimately contributing to prevention strategies for male reproductive birth defects.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $419.7k | 4/2/26 |