Project Grant K99HD119268
- The federal Project Grant award titled "MECHANISMS OF DOUBLE STRAND BREAK REPAIR IN FETAL MALE GERM CELLS" was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $107,458 award, granted on May 1, 2025, supports research at Duke University to determine how male germ cells in the fetal stage repair double-strand DNA breaks and maintain genomic...
- The federal Project Grant award of $561,097 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research by Yale University to investigate the genetic basis and molecular mechanisms underlying reduced sperm motility, a leading cause of male infertility. The research aims to capitalize on the university's access to large consanguineous Pakistani families with abnormal semen...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", provides $125,814 to support research on quantifying germ cell lineage dynamics in mammalian oogenesis (female egg cell development). The award aims to characterize the process of germ cell selection and the functional importance of early germ cell heterogeneity in shaping the developing ovarian...
- This federal Project Grant award of $2,207,672.00, awarded on August 1, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports genetic research on large palindrome arrays in mammalian genomes. The research aims to comprehensively characterize seven large palindrome arrays in mice, testing the hypotheses that these arrays evolve to favor their own inheritance and are necessary...
- This $616,841 project grant was awarded by the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", to Yale University beginning on August 15, 2025 and scheduled for completion on April 30, 2030. The project aims to investigate the molecular mechanisms that regulate genome activation and gene expression during embryonic development in vertebrates, with a focus on understanding how specific...
- This federal Project Grant award, valued at $380,546.00 and issued on January 20, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research at Children's Hospital Medical Center in Cincinnati, Ohio to investigate the post-transcriptional regulation of gene expression programs that govern the function of spermatogonial stem and progenitor cells in the mouse model. The...
- The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
- This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to...
- The Project Grant award titled "UNDERSTANDING FUNCTIONS OF LTR RETROTRANSPOSON ACTIVATION IN PREIMPLANTATION DEVELOPMENT" is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $401,927 award supports research to understand how long terminal repeat (LTR) retrotransposons regulate zygotic gene activation and early embryogenesis. The research...
This federal Project Grant award of $128,898 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to elucidate how the 3D genome regulates the transcriptional program during mouse spermatogenesis, with the goal of providing insight into how male germ cell identity is established. The principal investigator will perform high-resolution Hi-C analysis in the male germline to determine how the 3D chromatin structure in male germ cells changes dynamically during spermatogenesis, and how this 3D genome structure predetermines the transcriptional program that directs spermatogenic differentiation. The research aims to contribute to the treatment of male infertility and improvement of human reproductive success. The award period is from Aug 1, 2025 to Jul 31, 2027, and the research will be conducted at the University of California, Davis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.9k | 7/29/25 |