Project Grant R61MH138703
- This federal Project Grant award of $777,016.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a study on the synaptic mechanisms underlying repetitive transcranial magnetic stimulation (rTMS) protocols for the treatment of treatment-resistant depression. The study, titled "Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression," aims to investigate the neural mechanisms of the inhibitory...
- This federal Project Grant award, titled "MAINTENANCE RTMS FOR DEPRESSION (MAITR-DE)", is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $968,769 award will support a multi-site study to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) in sustaining treatment response for individuals with treatment-resistant depression. The study will be conducted by the University of...
- The National Institute of Mental Health (NIMH) awarded a $1,199,261 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Ampa Inc. The grant, awarded on September 15, 2025, will fund the development of a next-generation Transcranial Magnetic Stimulation (TMS) system that aims to make highly effective, personalized depression treatment more accessible and scalable. The key innovations include precision TMS targeting using neurocardiac response signals, camera-based...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $236,098 to The Trustees of the University of Pennsylvania to elucidate the glutamatergic mechanisms of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder. The research aims to use cutting-edge ultra-high field (7T) neuroimaging techniques, including glutamate chemical exchange saturation transfer...
- This Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to establish reliable markers of prefrontal excitability that can be used to optimize repetitive transcranial magnetic stimulation (rTMS) treatment for depression. The $784,096 award, with a project period from May 1, 2025 to February 28, 2030, will allow researchers at The Leland Stanford Junior University to: 1) investigate how...
- The National Institute of Mental Health (NIMH) awarded a $830,409 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, to develop novel software and computational techniques that integrate real-time navigated electric-field mapping and source-space electroencephalogram (EEG) analysis during transcranial magnetic stimulation (TMS) to improve the accuracy of targeting and dosimetry for...
- The National Institute of Mental Health (NIMH) awarded a $156,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Emory University to identify patients with true treatment failure for major depressive disorder (MDD) who may benefit from earlier referral to alternative treatments like transcranial magnetic stimulation, ketamine, and vagus nerve stimulation. The project aims to use trajectory classification methods to empirically separate partial response from true...
- This is a $223,176 Project Grant awarded by the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), to Beth Israel Deaconess Medical Center, Inc. in Boston, MA. The grant funds a research project that aims to use high-definition transcranial direct current stimulation (HD-tDCS) to the right superior temporal sulcus (rSTS) as a potential treatment approach for reducing auditory and visual hallucinations associated with psychosis-spectrum...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA 93.242 Mental Health Research Grants program, will provide $1,651,499.00 over 3 years to Magnetic Tides, Inc. to assess the proof-of-mechanism and efficacy of their novel Kilohertz Transcranial Magnetic Perturbation (KTMP) device for treating anhedonia in patients with major depressive disorder. The goal is to use KTMP to precisely modulate brain activity in the reward circuitry, specifically targeting the...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a study to evaluate the use of repetitive transcranial magnetic stimulation (rTMS) to the bilateral insula and lateral prefrontal cortex for treating depression in patients with schizophrenia spectrum disorders. The $1,125,194 award to the University of Texas Health Science Center at Houston will fund a two-phase study. The first R61 phase will assess whether the proposed rTMS stimulation strategy significantly engages the neural circuitry mechanisms linked to depression in schizophrenia over a 2-year period. If successful, the project will then proceed to a 3-year R33 phase to further evaluate the efficacy of this novel rTMS approach. The study aims to develop an alternative stimulation strategy that may be more effective than the commonly used rTMS to the dorsolateral prefrontal cortex for treating this challenging comorbidity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/5/25 | ||
| Not listed | $1.1m | 8/5/25 |