This federal Project Grant award of $709,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to establish a well-characterized cohort of individuals with post-tuberculosis lung disease (PTLD) in Uganda. The key objectives are to determine whether sex, HIV serostatus, and air pollution exposure are associated with distinct lung function and chest imaging phenotypes of PTLD. The award will support the enrollment of 650 post-TB and 165 non-TB...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $690,538 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Washington for the project "EXPANDING ACCESS AND IMPACT OF TUBERCULOSIS PREVENTIVE THERAPY: COMMUNITY-FRIENDLY DELIVERY AND MONITORING OF TPT TO IMPROVE UPTAKE AND REDUCE TB TRANSMISSION." The project aims to explore new, person-friendly models of tuberculosis preventive therapy (TPT) delivery to...
The University of Washington received a $233,250 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, awarded on September 25, 2025, will be used to evaluate the extent and outcomes of isoniazid (INH) exposure during pregnancy among infants born to women living with HIV-tuberculosis (TB) in high-burden settings. The project will quantify...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting a research project titled "Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease". The $187,461 award will be used to 1) define the clinical patterns of post-tuberculosis lung disease (PTLD) and associated outcomes to identify those most in need of pulmonary rehabilitation (PR); 2) develop a structured process for...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to characterize metabolic profiles and outcomes among tuberculosis (TB) patients in Tanzania. The $201,549 award to the Medical University of South Carolina will fund a 5-year study with the following objectives: Measure and describe metabolic markers and TB severity at the time of TB diagnosis, testing...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $278,390 to The Regents of the University of California, San Francisco (UCSF) to conduct research evaluating the potential role of the ESAT-6 antigen in Mycobacterium tuberculosis infection and vaccine development. The project aims to determine whether ESAT-6 serves as a "decoy antigen" that does not induce protective immunity against...
This $190,892 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support a study to optimize tuberculosis (TB) active case finding strategies in Nairobi, Kenya. The key products and services to be delivered include: Employing multiple data sources on human mobility and activity spaces to identify high-yield geographic locations for TB screening within Nairobi. Developing a geospatial model to estimate...
This $830,261 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports research on post-tuberculosis (TB) lung disease among individuals successfully treated for TB in Lima, Peru. The project, titled "Host- and Pathogen-Specific Risk Factors for Post-Tuberculosis Lung Disease among People Successfully Treated for TB in Lima, Peru: BEAT-PTLD," will evaluate 1,000 TB patients and 291 community...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $256,504 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF). The grant will fund the planning of an open-label, randomized, controlled Phase 2C clinical trial to evaluate novel 4-month treatment regimens for isoniazid-monoresistant tuberculosis (IMR-TB) compared to the current 6-month standard of care. The trial...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,265,657 to the Regents of the University of California, San Francisco (UCSF) to conduct a randomized trial to determine optimal tuberculosis (TB) screening and preventive therapy delivery strategies to improve maternal and birth outcomes among pregnant women with HIV in Uganda.
The study aims to evaluate the effectiveness of using C-reactive protein (CRP) screening and short-course TB preventive therapy (TPT) regimens, compared to standard symptom screening and longer TPT regimens, in reducing the TB burden and improving pregnancy outcomes for this high-risk population. This innovative, two-stage randomized trial leverages UCSF's expertise in infectious disease research, maternal health, and clinical trials to generate critical evidence to inform global guidelines and improve clinical practice. The award period runs from September 2025 through August 2026.