Project Grant R01HL180273
- This $830,261 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports research on post-tuberculosis (TB) lung disease among individuals successfully treated for TB in Lima, Peru. The project, titled "Host- and Pathogen-Specific Risk Factors for Post-Tuberculosis Lung Disease among People Successfully Treated for TB in Lima, Peru: BEAT-PTLD," will evaluate 1,000 TB patients and 291 community...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting a research project titled "Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease". The $187,461 award will be used to 1) define the clinical patterns of post-tuberculosis lung disease (PTLD) and associated outcomes to identify those most in need of pulmonary rehabilitation (PR); 2) develop a structured process for...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $897,448 to The Johns Hopkins University to conduct research on the causality of post-tuberculosis (TB) lung disease in rural Uganda. The study aims to evaluate lung function and respiratory symptoms both before and after TB diagnosis to better understand how much post-TB sequelae reflect the TB disease...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,136,143 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to study post-tuberculosis lung disease (PTLD) in youth with and without HIV globally. The project will leverage the Tuberculosis Sentinel Research Network (TB-SRN) in 11 countries to establish the prevalence of PTLD in youth, identify modifiable risk factors, and assess the impact on quality of life....
- This $854,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to assess post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The project will utilize novel positron emission tomography (PET) imaging techniques, such as 11C-rifampin PET, to longitudinally profile lesional characteristics and antibiotic exposures in animal models...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate...
- This $136,718 Project Grant award from the National Institutes of Health's Fogarty International Center (CFDA 93.989 - International Research and Research Training) supports a study to investigate the long-term respiratory health impacts of pulmonary tuberculosis in children and adolescents in The Gambia. The project, led by Principal Investigator Dr. Esin Nkereuwem from the Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, aims to: 1) characterize...
- This federal Project Grant award of $639,474, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports a study to investigate the impact of maternal mental health interventions on child respiratory health. The study aims to leverage an ongoing birth cohort in rural Pakistan to generate evidence on how childhood adversity, such as poverty and maternal depression, affects respiratory function and symptoms in early...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) in the amount of $293,395 provides funding to the University of Connecticut Health Center to conduct research on democratizing access to effective air purification devices to reduce particulate air pollution (PM2.5) exposure and prevent adverse health outcomes. The project involves three main activities: 1) conducting focus groups and interviews to refine the...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $446,875 to The Trustees of the University of Pennsylvania to evaluate the use of Fibroblast Activation Protein (FAP) Positron Emission Computed Tomography (FAP PET/CT) imaging to characterize lung fibrosis in adult pulmonary tuberculosis (TB) patients. The research aims to determine how changes in FAP radiographic...
This federal Project Grant award of $709,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to establish a well-characterized cohort of individuals with post-tuberculosis lung disease (PTLD) in Uganda. The key objectives are to determine whether sex, HIV serostatus, and air pollution exposure are associated with distinct lung function and chest imaging phenotypes of PTLD. The award will support the enrollment of 650 post-TB and 165 non-TB adults to investigate the impact of sex and HIV on lung function, total lung capacity, and diffusing capacity, as well as whether sex or HIV modifies the associations between PM2.5 air pollution exposure and PTLD. This study builds upon the research team's prior findings of significant sex-based and HIV-specific differences in respiratory outcomes post-pneumonia and preliminary data indicating similar trends post-TB. The award has an end date of May 31, 2030 and is being led by researchers at the University of California, San Francisco.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $148.7k | 8/2/25 | ||
| Not listed | $561.2k | 7/31/25 |