Project Grant R01HL180294
- This $830,261 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports research on post-tuberculosis (TB) lung disease among individuals successfully treated for TB in Lima, Peru. The project, titled "Host- and Pathogen-Specific Risk Factors for Post-Tuberculosis Lung Disease among People Successfully Treated for TB in Lima, Peru: BEAT-PTLD," will evaluate 1,000 TB patients and 291 community...
- This federal Project Grant award of $709,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to establish a well-characterized cohort of individuals with post-tuberculosis lung disease (PTLD) in Uganda. The key objectives are to determine whether sex, HIV serostatus, and air pollution exposure are associated with distinct lung function and chest imaging phenotypes of PTLD. The award will support the enrollment of 650 post-TB and 165 non-TB...
- This Project Grant award of $720,526 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of the TBC1D2B protein in the formation of new blood vessels and vascularization after ischemic injury. The funded research aims to uncover the underlying regulatory mechanisms by which the TBC1D2B protein, which interacts with phosphatidylinositol lipids, impacts the formation of endothelial cell tubes crucial for...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting a research project titled "Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease". The $187,461 award will be used to 1) define the clinical patterns of post-tuberculosis lung disease (PTLD) and associated outcomes to identify those most in need of pulmonary rehabilitation (PR); 2) develop a structured process for...
- This $854,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to assess post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The project will utilize novel positron emission tomography (PET) imaging techniques, such as 11C-rifampin PET, to longitudinally profile lesional characteristics and antibiotic exposures in animal models...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $446,875 to The Trustees of the University of Pennsylvania to evaluate the use of Fibroblast Activation Protein (FAP) Positron Emission Computed Tomography (FAP PET/CT) imaging to characterize lung fibrosis in adult pulmonary tuberculosis (TB) patients. The research aims to determine how changes in FAP radiographic...
- This federal Project Grant award of $788,478 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Texas Medical Branch at Galveston (UTMB) to investigate the role of C-type lectin receptor (CLR) signaling through the macrophage galactose-type lectin (MGL) in regulating macrophage immune metabolism and the host lipid response during Mycobacterium tuberculosis (MTB) infection. The research aims to 1) identify how...
- This $209,408 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports a research project to characterize the role of unconventional T cell subsets in the immune response to Mycobacterium tuberculosis (MTB) infection using a non-human primate model. The goal is to gain a better understanding of these niche T cell populations in the lung granulomas during the early stages of MTB...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program for Cardiovascular Diseases Research (CFDA 93.837), provides $123,104 to Emory University to conduct research on factors contributing to cardiovascular disease (CVD) comorbidities in persons living with HIV (PWH). The key objectives are to: 1) assess relationships between the metabolome, lipidome, HIV reservoir, and subclinical CVD, analyzing differences by sex; and 2) determine...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate the role of inflammasomes and the impact of pulmonary involvement severity on vascular outcomes after TB treatment. This 4-year project aims to identify high-risk patients and enable early interventions to reduce the significant cardiovascular morbidity and mortality faced by TB survivors, a major public health challenge.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 9/19/25 | ||
| Not listed | ($678k) | 9/17/25 | ||
| Not listed | $678.2k | 8/29/25 |