Project Grant R61AG102807
- The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $451,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to model age-dependent HSP90 decline and genome instability in mammals. The project examines how heat shock protein 90 (HSP90), a sentinel of protein homeostasis, buffers deleterious mutations in critical DNA repair proteins FANCA and BRCA1, and investigates how HSP90's buffering capacity diminishes with age. The research uses...
- The National Institute on Aging awarded a $7.287 million cooperative agreement to Arizona State University on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds a five-year research initiative running through August 31, 2031, examining heterogeneity in aging using a free-ranging rhesus macaque population on Cayo Santiago Island, Puerto Rico—the world's longest-running primate field station. The research program addresses three integrated questions: quantifying how...
- The National Institute on Aging awarded Baylor College of Medicine $430,212 under the Aging Research program (CFDA 93.866) on September 1, 2026, for an exploratory R21 project to establish Procotyla fluviatilis, a North American planarian species, as a comparative model for aging research. The funded work will define how stem cell function and tissue structure change across the flatworm's seasonal life cycle, map age-associated cellular and transcriptional changes using single-cell sequencing,...
- The National Institute on Aging awarded Baylor College of Medicine $440,000 on May 1, 2026, under the Aging Research program (CFDA 93.866) to conduct single-cell transcriptomic and epigenomic analysis of budding yeast aging. The project, titled "Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity Through Yeast Single-Cell Aging Atlases," investigates the molecular basis for lifespan variation in genetically identical organisms raised in controlled conditions. The...
- The National Institute on Aging awarded Baylor College of Medicine $689,188 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate hepatic epigenetic memory mechanisms and metabolic resilience in aging-related metabolic disease. The award funds research examining how high-level estrogen exposure—mimicking pregnancy—initiates persistent chromatin accessibility and histone hyperacetylation at an enhancer region of the transcription factor BNC2 in liver tissue. The...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded Texas A&M University $640,059 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebellar changes in aging and cognitive decline through longitudinal neuroimaging and functional analysis. The project examines how cerebellar structure, white matter circuits, and task-based functional activation change over time in older adults, with particular focus on individuals experiencing subjective cognitive decline—self-reported...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Baylor College of Medicine $440,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop human proteins that suppress DNA damage as potential agents for cellular and genome protection. The project tests the hypothesis that human proteins functioning as molecular shields can protect cells and DNA from damage, reduce somatic mutation rates, and potentially delay or prevent...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Old Dominion University $160,000 on September 1, 2026, to develop and test a three-dimensional bioprinted mammary model system for investigating age-related cellular dysfunction and regenerative microenvironment mechanisms under the Aging Research program (CFDA 93.866). The project addresses molecular mechanisms underlying cellular and tissue rejuvenation through a regenerative microenvironment model....
The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $628,988 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a nonhuman primate research infrastructure for studying female aging and perimenopause. The award funds development of a comprehensive baboon research infrastructure anchored at the Keeling Center for Comparative Medicine and Research. In the R61 phase, the recipient will assess feasibility and validity of key methods to characterize perimenopause in 24 aging female baboons, including training for urine collection to enable hormonal assays, using anogenital swelling variation as a proxy for hormonal profiles, and monitoring cardiovascular and physical activity via minimally invasive implants. In the subsequent R33 phase, the recipient will expand the cohort to the oldest 51 female baboons and implement a longitudinal design to capture multimodal data across neurological, endocrine, physiological, behavioral, and cognitive domains. The recipient will integrate behavioral, endocrine, cognitive, neuroimaging, biomarker, and physiological data into the National Baboon Research Resource portal and harmonize measures with human cohort datasets such as MIDUS using construct mapping to ensure translational validity. The recipient will also develop a scoring system for early life stress based on medical and rearing histories, paralleling human cumulative stress models. Period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Houston, Texas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $629.0k | 9/2/26 |