Project Grant R01AG097608
- The National Institute on Aging awarded Baylor College of Medicine $440,000 on May 1, 2026, under the Aging Research program (CFDA 93.866) to conduct single-cell transcriptomic and epigenomic analysis of budding yeast aging. The project, titled "Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity Through Yeast Single-Cell Aging Atlases," investigates the molecular basis for lifespan variation in genetically identical organisms raised in controlled conditions. The...
- The National Institute on Aging awarded Baylor College of Medicine $101,052 under the Aging Research program (CFDA 93.866) on December 25, 2026, to characterize the role of CARHSP1 (calcium-regulated heat stable protein 1) in the aging brain and Alzheimer's disease. The funded research will define the role of CARHSP1 and its Drosophila homolog CG9705 in normal neuronal function through loss- and gain-of-function modeling; identify genetic interactions that mediate CARHSP1-induced toxicity by...
- The National Institute on Aging awarded Baylor College of Medicine $430,212 under the Aging Research program (CFDA 93.866) on September 1, 2026, for an exploratory R21 project to establish Procotyla fluviatilis, a North American planarian species, as a comparative model for aging research. The funded work will define how stem cell function and tissue structure change across the flatworm's seasonal life cycle, map age-associated cellular and transcriptional changes using single-cell sequencing,...
- The National Institute on Aging awarded the University of Pennsylvania $2,809,832 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic mechanisms driving cellular aging and age-associated disease. The award funds four integrated research projects examining chromatin homeostasis ("chromostasis") and senescence-associated secretory phenotype (SASP) in aging tissues. The research hypothesizes that age-related epigenetic changes result from...
- The National Institute on Aging awarded Emory University $782,500 under the Aging Research program (CFDA 93.866) on February 1, 2026, to examine how reproductive events influence biological aging processes and menopause timing among Latina women. The award funds analysis of reproductive events—including puberty, pregnancy, and menopause—and their associations with epigenetic aging and menopause in a sample of pre-menopausal Latina women participating in the Hispanic Community Health...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $1,308,220 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic modulation by Enhancer of Zeste Homolog 2 (EZH2) in cerebral amyloid angiopathy and Alzheimer's disease. The research examines how EZH2, a master epigenetic modifier, controls endothelial nitric oxide synthase (eNOS) and claudin-5 tight-junction protein expression in cerebral vasculature. The...
- The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $628,988 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a nonhuman primate research infrastructure for studying female aging and perimenopause. The award funds development of a comprehensive baboon research infrastructure anchored at the Keeling Center for Comparative Medicine and Research. In the R61 phase, the recipient will assess feasibility and validity...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Baylor College of Medicine $440,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop human proteins that suppress DNA damage as potential agents for cellular and genome protection. The project tests the hypothesis that human proteins functioning as molecular shields can protect cells and DNA from damage, reduce somatic mutation rates, and potentially delay or prevent...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $761,496 on June 15, 2026, to investigate epigenetic mechanisms linking delirium and cognitive decline under the Aging Research program (CFDA 93.866). The recipient will test the hypothesis that epigenetic risk, measured by DNA methylation, identifies individuals with a vulnerable brain predisposed to delirium, cognitive decline, and Alzheimer's disease and Alzheimer's disease-related dementias in the setting of...
- The National Institute on Aging awarded Epicypher, Inc. a $3.747976 million Project Grant (R44AG091990) on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop AgingPTMTM, a novel platform for studying aging-associated combinatorial histone post-translational modifications (HPTMs) in tissue. The platform will enable identification and study of new therapeutic targets and biomarkers relevant to aging and Alzheimer's disease and related dementias. HPTMs regulate...
The National Institute on Aging awarded Baylor College of Medicine $689,188 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate hepatic epigenetic memory mechanisms and metabolic resilience in aging-related metabolic disease. The award funds research examining how high-level estrogen exposure—mimicking pregnancy—initiates persistent chromatin accessibility and histone hyperacetylation at an enhancer region of the transcription factor BNC2 in liver tissue. The research tests whether this epigenetic memory, latent after estrogen cessation, can be retrieved by high-fat diet challenge to confer metabolic resilience including improved glucose tolerance, reduced liver triglycerides, and lower blood cholesterol levels. The project uses hepatocyte-specific estrogen receptor depletion, CRISPRi-mediated epigenetic suppression of the BNC2 enhancer, and targeted histone acetylation elevation to determine causality and identify the mechanisms by which pregnancy-associated estrogen initiates and maintains the epigenetic memory and how overnutrition retrieves it. Work is performed in Houston, Texas with a period of performance extending through July 31, 2031. This is a Project Grant, the standard assistance type under the Aging Research program, supporting biomedical research directed toward understanding aging processes and age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.2k | 8/12/26 |