Project Grant R21AG103389
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Baylor College of Medicine $440,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop human proteins that suppress DNA damage as potential agents for cellular and genome protection. The project tests the hypothesis that human proteins functioning as molecular shields can protect cells and DNA from damage, reduce somatic mutation rates, and potentially delay or prevent...
- The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $628,988 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate a nonhuman primate research infrastructure for studying female aging and perimenopause. The award funds development of a comprehensive baboon research infrastructure anchored at the Keeling Center for Comparative Medicine and Research. In the R61 phase, the recipient will assess feasibility and validity...
- The National Institute on Aging awarded Baylor College of Medicine $101,052 under the Aging Research program (CFDA 93.866) on December 25, 2026, to characterize the role of CARHSP1 (calcium-regulated heat stable protein 1) in the aging brain and Alzheimer's disease. The funded research will define the role of CARHSP1 and its Drosophila homolog CG9705 in normal neuronal function through loss- and gain-of-function modeling; identify genetic interactions that mediate CARHSP1-induced toxicity by...
- The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $100,802 on August 1, 2026, under the Aging Research program (CFDA 93.866) to support Dr. Shim's research into the impact and therapeutic effects of selective telomerase reverse transcriptase (TERT) activation in Alzheimer's disease. Dr. Shim, an instructor at MD Anderson Cancer Center, will conduct mechanistic research elucidating how TERT contributes to natural aging and age-related diseases, with...
- The National Institute on Aging awarded Massachusetts Institute of Technology $723,962 on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a systems-level analysis of DNA damage and repair in senescence, aging, and cancer. The research applies mass spectrometric adductomics and an in vivo host cell reactivation assay to define the spectrum of DNA adducts in human cells, identify adducts that accumulate in senescing cells and drive replication stress, assess how...
- The National Institute on Aging awarded Baylor College of Medicine $440,000 on May 1, 2026, under the Aging Research program (CFDA 93.866) to conduct single-cell transcriptomic and epigenomic analysis of budding yeast aging. The project, titled "Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity Through Yeast Single-Cell Aging Atlases," investigates the molecular basis for lifespan variation in genetically identical organisms raised in controlled conditions. The...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $249,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate an innovative genetic platform for de-risking g-secretase modulator therapeutics in Alzheimer's disease. The award funds two primary aims. Aim 1 involves using CRISPR/Cas9 engineering and structure-informed design to generate and validate a novel...
- The National Institute on Aging awarded the University of Texas Health Science Center at Houston $429,000 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cellular thermogenesis and lifespan modulation mechanisms in Drosophila melanogaster exposed to cold temperatures. The research examines how exposure to low temperature (18°C) extends lifespan in fruit flies by more than 200 days, more than double the lifespan of flies maintained at 25°C. The project tests three...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,898 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct functional genetic analyses of healthspan in humans. The recipient will identify shared genetic architecture underlying age-related diseases and aging-related traits, experimentally validate the regulatory roles of healthspan-associated non-coding variants and their target genes, and elucidate molecular...
The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $451,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to model age-dependent HSP90 decline and genome instability in mammals. The project examines how heat shock protein 90 (HSP90), a sentinel of protein homeostasis, buffers deleterious mutations in critical DNA repair proteins FANCA and BRCA1, and investigates how HSP90's buffering capacity diminishes with age. The research uses biochemistry and single-cell genomics methodologies to demonstrate that HSP90-buffered mutations cause genome instability when HSP90 expression declines—a phenomenon observed in aging tissues in both animal models and humans. The award funds hypothesis-testing in mice carrying HSP90-buffered mutations to determine whether they develop age-related phenotypes corresponding to reduced HSP90 activity, addressing a fundamental gap in understanding how heritable mutations couple to late-age disease expression. Work is performed at MD Anderson's Houston, Texas location. The period of performance runs from September 1, 2026, through August 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/26/26 |