Project Grant R61AA031291

Award Date 9/25/24
Completion Date 8/31/26
Dollars Obligated $725K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
California, USA
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The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $725,192 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Leland Stanford Junior University. The grant, awarded on Sep 25, 2024, aims to develop treatments for mental deficiencies caused by fetal alcohol exposure. Specifically, the project will:

  1. Characterize the dose-response relationship for the drug vinpocetine in animal models of fetal alcohol spectrum disorders (FASD) to determine effective dosing levels.

  2. Assess the maximum tolerated oral dose of vinpocetine in healthy adult volunteers and gather pharmacokinetic data.

  3. Establish a research team, develop study tools and protocols, and prepare for future Phase I and Phase II clinical trials to evaluate the safety and potential cognitive efficacy of vinpocetine treatment for adolescents and adults with FASD.

The proposed research seeks to advance the understanding and treatment of the lifelong impairments associated with prenatal alcohol exposure through a comprehensive translational approach spanning animal models and human clinical studies.

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