The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $119,253 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of New Mexico Health Sciences Center. The grant will fund research to investigate the impact of third trimester alcohol exposure on sharp-wave ripples, a key neural mechanism for learning and memory, in the hippocampal-retrosplenial cortex circuit. The project will utilize a mouse model, in vivo electrophysiology, and optogenetics...
This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a postmortem, multi-omic study of brains from 341 total subjects to identify novel lasting transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research will analyze RNA sequencing and whole-genome bisulfite sequencing data across 8 brain...
This Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate the neural mechanisms driving adaptive stress coping behaviors and subsequent alcohol use. The $498,121.57 award, effective August 15, 2024 through July 31, 2027, will utilize an animal model to explore how dysfunction in the corticolimbic circuitry, specifically the prelimbic cortex and basolateral...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,547,718 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from September 1, 2024 to May 31, 2029. The project will investigate the role of KDM5 demethylases in regulating cell-cell communication in the development and resolution of alcohol-associated liver disease. Specifically, the research aims to determine how KDM5B and KDM5C...
This $317,534.10 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to understand the metabolic disruptions that lead to fetal growth deficits in prenatal alcohol exposure (PAE). The researchers at the University of North Carolina at Chapel Hill will quantify how alcohol alters maternal-fetal glucose and insulin signaling, with the goal of identifying the underlying mechanisms that...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...
This federal Project Grant award of $151,869, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research to investigate the relationship between chronic alcohol consumption, metabolic dysfunction, and the progression of Alzheimer's disease (AD). The key objectives of this 2-year project include: 1) assessing the impact of chronic ethanol exposure on metabolic function and tau pathology in an AD mouse...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, provides $499,442 in funding to The Regents of the University of California, San Francisco (UCSF) from August 20, 2024 through July 31, 2027. The award supports research to investigate the role of brain-derived neurotrophic factor (BDNF) signaling in the ventral hippocampus and its contribution to the acute anxiolytic and social...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $128,481 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of New Mexico Health Sciences Center (UNM HSC) to investigate potential therapeutic interventions to restore hippocampal neurogenesis in a mouse model of fetal alcohol spectrum disorder (FASD). The 3-year project aims to determine if pharmacological, genetic, or activity-based approaches can reinstate the neurogenic response to...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under CFDA Program 93.273 Alcohol Research Programs, provides $148,568 to the University of California, Los Angeles (UCLA) to conduct research on the neuroepigenetic mechanisms underlying the transgenerational effects of alcohol exposure.
The key objectives of this research project are to:
Identify the neuronal epigenetic changes, particularly histone acetylation patterns, that accompany alcohol exposure using state-of-the-art sequencing and imaging approaches.
Determine the role of neuronal histone acetylation in driving the transgenerational behavioral effects of alcohol exposure through genetic, epigenetic, and pharmacological manipulations in the model organism C. elegans.
This work will be carried out in the laboratories of experts in environmental epigenetics and fetal alcohol spectrum disorders, and aims to advance the fundamental understanding of how the memory of alcohol exposure is encoded and transmitted across generations at the neuroepigenetic level. The award period is from January 20, 2025 to November 30, 2025.