This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of FLT3 signaling in regulating GABAergic inhibition and seizure susceptibility. The total funding amount is $1,586,667 over the project period from July 1, 2024 to May 31, 2029. The research will be conducted by The Children's...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
This Project Grant award of $481,250.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in specific neuron subtypes and contexts. The award to President and Fellows of Harvard College will enable the investigation of subcellular mechanisms controlling neural...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), provides $864,515 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on the functional characterization of cell surface RNA biology. The project aims to explore three key hypotheses related to the molecular, biochemical and biophysical activities of cell surface RNA-binding...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to identify novel genetic causes of infantile epilepsies and evaluate the clinical and familial impact of genetic diagnoses. The $230,904 award to The Children's Hospital Corporation (doing business as Boston Children's Hospital) will fund a 5-year...
This is a Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Children's Hospital Corporation (dba Boston Children's Hospital) for $2,672,344, with a period of performance from September 1, 2024 to May 31, 2029. The project aims to examine whether the accumulation of somatic mutations contributes to an age-related increase in Alzheimer's disease (AD) risk by driving clonal expansion of microglia, which can induce neuroinflammation and neuronal loss in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $687,279 to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research aimed at dissecting the immune responses and cellular composition within the glioblastoma (GBM) tumor microenvironment. The research will leverage archival patient samples and mouse...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,630.00 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to study the role of the EIF4A2 gene in interneuron development using zebrafish models. The 5-year award period runs from August 10, 2024 to July 31, 2029. The research aims...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $218,068 to The Children's Hospital of Philadelphia (CHOP) to conduct research on mechanisms of glial detection and facilitation of axonal regeneration. The research aims to uncover novel mechanisms of glial recovery and glial facilitation of axon regeneration, which...