Project Grant R56NS144817
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $435,829 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigation of gut-brain communication mechanisms underlying behavioral state transitions. The research, led by the Alkema Lab, examines how internal states and environmental cues integrate to regulate behavior in C. elegans, using the organism's defined neural circuits, genetic...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $119,286 on August 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the functional roles of microbial metabolites in HIV-associated neurocognitive disorders (HAND). The research integrates metabolomics, metagenomics, in vitro and in vivo assays, and computational approaches to address gaps in understanding...
- The National Institute of Neurological Disorders and Stroke awarded Rosalind Franklin University of Medicine & Science $396,015 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support molecular characterization of genes regulating CAV2 voltage-gated calcium channels and their roles in channel trafficking and degradation. The research uses C. elegans as a model organism to identify and characterize genes...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Massachusetts Institute of Technology $129,168 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on the modulation of autonomic function by affective pain pathways. The research interrogates the role of the parabrachial-limbic circuit and...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts $202,066 on August 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing R01NS153765) to develop computational algorithms that identify and track individual neurons in gastropod mollusk brains across developmental and evolutionary time. The project will expand the FishExplorer software platform from fish to...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate time-dependent membrane proteomics in circadian pacemaker neurons. The recipient will use cutting-edge proteomic approaches combined with biotin proximity labeling to survey the membrane proteome of circadian neurons during the...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $542,777 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and functionally analyze somatic mutations contributing to sporadic amyotrophic lateral sclerosis. The research combines clinical expertise in ALS genetics with expertise in somatic mutations and single-cell analysis to investigate...
The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $578,007 on August 1, 2026, for research on the gut-brain axis and microbial impact on neural function under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates mechanistic links between diet, gut microbiota, and neurological disorders including depression, migraine, anxiety, autism, schizophrenia, and neurodegenerative diseases. The work uses Caenorhabditis elegans mutants carrying a gain-of-function mutation in the voltage-gated calcium channel gene UNC-2/CAV2A as a model system. Preliminary findings show that specific bacterial diets reduce seizure behavior in these mutants, and that vitamin B12 and nitric oxide-producing bacteria alter C. elegans behavior. The research aims to identify microbiome-derived factors that modulate neural function and establish how bacterially derived nitric oxide regulates neurotransmitter release, synaptic plasticity, and neuroprotection. Performance runs from August 1, 2026, through July 31, 2027, at the University of Massachusetts Medical School in Worcester, Massachusetts. This is a one-year Project Grant supporting basic research in neurological science and disease mechanisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $578.0k | 8/3/26 |