Project Grant R21NS146961
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $630,925 on May 1, 2026, to investigate circadian clock physiology in cortico-limbic brain circuits and its role in regulating complex behavioral states including mood, memory, and executive function. The research examines how transcriptional timing feedback loops and clock oscillators outside the suprachiasmatic nucleus operate at cellular and systems levels within cortico-limbic circuits, and how...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $711,952 under Project Grant R01NS144151 on May 2, 2026, to investigate circadian regulation of synaptic function and sleep-wake behavior. The research examines how circadian rhythms regulate synaptic function to modulate behavior with time of day, focusing on the molecular mechanisms by which the transcription factor BMAL1 and its phosphorylation at serine 42 orchestrate synaptic vesicle dynamics,...
- The federal Project Grant award R21NS136974 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $466,125 award to President and Fellows of Harvard College, doing business as Harvard Medical School, aims to analyze the composition of two BMAL1 circadian clock complexes purified from the mammalian brain and develop procedures for determining their...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $433,125 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate genes and neurons associated with circadian chronotype across Drosophila species. The project quantifies locomotor activity patterns across 63 related Drosophilid species to identify genetic and neural correlates of morning and evening...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $457,272 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate circadian rhythm regulation of the blood-brain barrier. The project examines how pericytes—mural cells in close contact with brain capillaries—strengthen circadian rhythms in brain endothelial cells, with a focus on the role of caveolin-1 (CAV1), a protein...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $648,672 on June 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate circadian regulation of reperfusion efficacy in acute ischemic stroke. The research employs a translational approach combining clinical neuroimaging, biomarkers, mouse models of stroke, CT-PET imaging of tissue...
- The National Institute of Neurological Disorders and Stroke awarded the Trustees of Boston University $170,132 under Project Grant F31NS145737 on December 1, 2025, to support research on the regulation of cerebral blood flow by intrinsic neuromodulation across wakefulness and sleep states. The award is made under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will examine neurovascular coupling through two coordinated aims....
- The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center $475,475 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of neurotensin-expressing neurons in the lateral hypothalamus in narcolepsy with cataplexy pathophysiology. The research examines whether enhancing lateral hypothalamic neurotensin neuron activity mitigates sleepiness and cataplexy...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $532,314 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how sleep pressure and circadian timing interact to impact hippocampal function and memory consolidation. The research examines how different periods...
The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate time-dependent membrane proteomics in circadian pacemaker neurons. The recipient will use cutting-edge proteomic approaches combined with biotin proximity labeling to survey the membrane proteome of circadian neurons during the day/night cycle. The research addresses how synchronized circadian molecular clocks in the brain's pacemaker neurons generate desynchronized neural activity rhythms that determine the timing of essential behaviors including sleep-wake cycles and feeding. The investigation hypothesizes that local circadian clocks regulate time-dependent and neuron-specific expression of membrane proteins such as ion channels and receptors. The recipient will test the function of rhythmic membrane proteins through circadian behavior and sleep screens to identify mechanisms by which circadian clocks determine temporal patterns of neural activity in diverse populations of pacemaker neurons. Performance occurs at Worcester, Massachusetts from August 1, 2026 through July 31, 2028. The award is classified as a Project Grant, an assistance type supporting extramural basic and clinical research in neuroscience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 7/20/26 |