Project Grant K99NS147878
- The National Institute of Neurological Disorders and Stroke awarded the University of Colorado a Project Grant totaling $184,506 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with an ultimate completion date of July 31, 2027, supports research investigating the dual roles of amyloid beta (AB) in central nervous system neuropathogenesis associated with HIV-Associated Neurocognitive Disorder...
- The National Institute on Aging awarded the University of California, San Diego $163,867 on July 1, 2026, under the Aging Research program (CFDA 93.866) to discover and classify metabolite biomarkers of neurocognitive impairment in older people with HIV using metabolomics and machine learning methods. The research leverages untargeted metabolomics data from fecal samples of 403 older people with HIV enrolled in cohort studies at UC San Diego's HIV Neurobehavioral Research Center to identify...
- The Scintillon Institute received a $1,025,015 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 11, 2025, with completion targeted for July 31, 2027. The award funds development of a next-generation preclinical NeuroHIV model to advance understanding of how Human Immunodeficiency Virus (HIV-1) affects the central nervous system...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,387,755 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mitochondrial oxidative phosphorylation dysregulation in HIV-associated neurocognitive disorder and opioid use disorder, with NAD+ treatment as a potential therapeutic strategy. The research establishes a three-dimensional human assembloid model composed of iPSC-derived neurons, astrocytes, microglia, and...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $129,186 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate metabolic plasticity and neuronal resilience in response to chronic mitochondrial DNA damage. The research will characterize mitochondrial DNA distribution and motility in healthy versus mitochondrial DNA-compromised neurons using two...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Mental Health awarded Drexel University $100,228 on December 16, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on HIV-induced trained immunity in microglia and its contribution to HIV-associated neurocognitive disorders (HAND). The project investigates whether trained immunity—a form of innate immune memory characterized by hyperresponsiveness to secondary inflammatory stimulation—occurs in microglial cells of people living with...
- The National Institute of Neurological Disorders and Stroke, an institute of the National Institutes of Health, awarded The Regents of the University of California, San Francisco $205,200 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the role of microglia in cortical interneuron development in genetic and environmental disruptions associated with autism spectrum disorder. The work...
- The National Institute on Drug Abuse, part of the Department of Health and Human Services National Institutes of Health, awarded the University of California, San Diego $192,930 in project grant funding on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports mentoring in patient-oriented research on central nervous system dysfunction in individuals with HIV and substance use. The funded activities provide protected time for the principal...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $578,007 on August 1, 2026, for research on the gut-brain axis and microbial impact on neural function under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates mechanistic links between diet, gut microbiota, and neurological disorders including depression, migraine, anxiety, autism, schizophrenia, and...
The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $119,286 on August 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the functional roles of microbial metabolites in HIV-associated neurocognitive disorders (HAND). The research integrates metabolomics, metagenomics, in vitro and in vivo assays, and computational approaches to address gaps in understanding how gut microbiome metabolites—particularly N-acyl lipids and bile acids—contribute to HAND pathogenesis. The work proceeds in two aims. The first uses the HIV-1 transgenic rat model to determine how antiretroviral therapy affects the metabolome, microbiome, behavior, and tissue distribution of microbial metabolites. The second evaluates the neuroinflammatory potential of N-acyl lipids and bile acids using stem cell-derived microglia, identifies their microbial sources by culturing synthetic gut communities and individual bacterial strains, and integrates multi-omic data to clarify producer organisms and biological function. The award supports research at UC San Diego's La Jolla, California campus. The period of performance runs from August 18, 2026, through July 31, 2028. This is a Project Grant, the standard assistance type for extramural research awards from NINDS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $119.3k | 8/18/26 |