This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $462,501 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, to conduct research on mast cell activation as a common mechanism of pulmonary toxicity from chemical threat agents. The two-year project aims to examine how activation of mast cells contributes to lung inflammation and injury caused by exposure to various chemicals including nitrogen mustard, formaldehyde, and chloropicrin. The research will utilize mouse models and human mast cell lines to investigate shared pathways leading to pulmonary toxicity, with the goal of identifying novel therapeutic targets. As a sub-award, $77,714 in funding has been provided to Henry Ford Health + Michigan State University Health Sciences to support specific aspects of the research. Overall, the project seeks to advance understanding of common mechanisms underlying the pulmonary effects of diverse chemical threat agents.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $462.5k | 8/18/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
FY24714001S | Henry Ford Health + Michigan State University Health Sciences | Project Grant R56ES034386 | $11.9k | 2/16/24 |