The federal Project Grant award R01HL177625, worth $616,814.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective January 15, 2025, supports research to establish the in vivo role of key microRNAs in regulating airway smooth muscle function and airway hyperresponsiveness, and to demonstrate how the dysregulation of these microRNAs contributes to human asthma and impacts response to asthma...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,237,267 to Oregon Health & Science University (OHSU) to study the mechanisms by which the neuropeptide substance P contributes to severe bronchoconstriction and inflammation in eosinophilic asthma. The 4-year project, awarded on June 15, 2024 and scheduled for completion by March 31, 2028, aims to elucidate the specific roles of...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $613,934 to North Dakota State University (NDSU) to investigate the role of the aryl hydrocarbon receptor (AhR) signaling in airway smooth muscle (ASM) and its impact on inflammation and remodeling in asthma. The key objectives are to: 1) determine the mechanisms of AhR expression and regulation in human ASM during inflammation...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $715,968 in funding to Brigham & Women's Hospital Inc. to conduct research on the mechanisms driving mast cell expansion and function in human airway diseases. The key objectives of this 5-year research project are to: 1) evaluate the concentration of mast cell progenitors in human sinonasal tissue across different disease...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,245,701 to the University of Pittsburgh to research mechanisms of allergen-induced tolerance in the lung. The goal is to develop a better understanding of how repeated exposure to low doses of allergens, such as house dust mite, can prevent adverse reactions upon subsequent exposure. Key focus areas include...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program will provide $636,843 to The Regents of the University of California, San Francisco (UCSF) to conduct research on targeting the stromal niche for tissue-resident lymphocytes (TRLs) in asthma. The key objectives are to characterize stromal factors that alter immune cell accumulation in the lung, define the effects of TRLs on airway...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $672,657 to support research on the role of transmembrane protein 178 (TMEM178) in asthma pathogenesis. The key objectives are to: 1) Investigate how TMEM178-mediated inhibition of calcium responses is disrupted in asthmatic bronchial epithelial cells; 2) Analyze the impact of targeted genetic loss of TMEM178 in the epithelium...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 (Cardiovascular Diseases Research) provides $177,403.00 to Brigham & Women's Hospital Inc. to conduct research aimed at understanding the heterogeneity and endotypes of asthma. The 5-year project, starting on September 1, 2024, will leverage multi-omics data from three cohorts of asthmatic children to analyze the interplay between genetic, epigenetic, and metabolomic factors in...
The federal Project Grant award K23HL174407, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate multifactorial determinants of asthma in underresourced pediatric populations. The $164,453 award to the Arkansas Children's Research Institute (ACRI) will examine asthma prevalence, morbidity, and healthcare utilization among racial/ethnic minority and rural children in Arkansas. By...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding the development of a novel mouse strain to study the role of intraepithelial mast cells in airway inflammatory diseases, such as asthma and nasal polyposis. The $960,135 award, with a project period from May 2024 to March 2026, will be used by the prime awardee, Brigham & Women's Hospital Inc., to...