The University of Chicago received a $260,000 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project, titled "Coordinated Cytoskeletal and Cell Adhesion Dynamics in Vesicant Induced Skin Injury," aims to investigate the basic molecular mechanisms underlying skin injury from chemical weapons exposure, with a focus on understanding how skin vesicants regulate cell adhesion and cytoskeletal dynamics through signaling pathways involving the ACF7 protein and focal adhesion kinase (FAK). The research will employ mouse models, cell culture experiments, and skin organoid cultures to explore potential therapeutic targets for treating chemical-induced skin damage. This award supports the university's expertise in cell adhesion and cytoskeletal dynamics research and contributes to advancing the development of effective medical countermeasures against chemical warfare agents.
Generated 3/4/25, 5:59 AM