The Project Grant award R56ES034423 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $445,500 to the University of Alabama at Birmingham (UAB) to study the role of extracellular vesicles (EVs) and exosomes as mediators of injury from inhaled exposures to toxic chemicals such as sulfur mustard and chlorine. The project aims to: (A) characterize EVs/exosomes derived from the bronchoalveolar lavage fluid and plasma of rats exposed to these chemicals, (B) identify mechanisms by which EVs/exosomes from exposed animals cause injury, and (C) evaluate the pathogenicity of EVs/exosomes and test inhibitors of their biogenesis or uptake. This research aims to delineate how EVs/exosomes influence pulmonary injury and disease severity, and determine if they can serve as therapeutic targets to mitigate organ damage from inhaled toxic chemical exposures.
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