Project Grant R56EB038401
- The National Institute of General Medical Sciences awarded $398,464 to the University of Oregon on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop photoresponsive biomaterials for directing the growth and differentiation of three-dimensional microphysiological tissue systems. The project focuses on creating smart, light-triggered biomaterials that provide spatial and temporal control over cell growth and differentiation in engineered tissues. The...
- The National Institute of Biomedical Imaging and Bioengineering awarded Oregon State University $560,293 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop cryopreservation methods that extend organ viability from hours to years through high throughput screening and machine learning for discovery of next-generation cryoprotective agents. The award supports research aimed at improving transplantation...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop lipid nanoparticle technology for simplified CRISPR/CAS9 gene editing in Caenorhabditis elegans nematodes. The funded work addresses a bottleneck in C. elegans research where microinjection of CRISPR guides limits throughput for genome-wide mutagenesis...
- The National Institute of Biomedical Imaging and Bioengineering awarded Oregon Health & Science University $195,000 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop engineered tissue models that illuminate cellular crosstalk required for early tumor development, specifically focusing on the transition from pancreatic ductal adenocarcinoma precursor lesions to invasive cancer. The project...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California Santa Cruz $234,750 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a de novo binder-luciferase platform for multiplexed protein detection in Western blots and lateral flow assays. The project will replace antibody-based detection reagents with computationally designed, thermostable de novo...
- The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $714,870 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop bifunctional small molecules for biosensing and continuous enzyme evolution. The project addresses two bottlenecks in directed enzyme evolution: the low throughput of classical analytical methods, which explore only 10² variants per round, and the labor-intensive manual operations between...
- The National Institutes of Health Office of the Director awarded The Leland Stanford Junior University $231,000 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to advance synthetic biology tools for engineering gut commensal bacteria as therapeutic agents. The project, titled "Advancing Synthetic Biology Tools for Engineering Gut Commensals" (R21EB037892), develops approaches to overcome current limitations in delivering engineered bacterial...
- This four-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences provides $885,852 to Oregon Health & Science University under the Biological Sciences program (CFDA 47.074) from August 2021 through July 2025. The funding supports quantitative exploration of molecular machine mechanisms to advance understanding of major challenges in biology. As the stated purpose of the Biological Sciences program is to promote progress in the field and...
- The National Science Foundation Division of Biological Infrastructure awarded the University of Oregon $1,051,508 on July 15, 2026, under the Biological Sciences program (CFDA 47.074) to investigate the genetic basis of regulatory evolution in threespine stickleback fish through single-cell genomic and computational approaches. The research determines which cell types respond to environmental shifts and how the same genetic variants produce different outcomes across environments, using...
- The National Institute of General Medical Sciences awarded the University of Oregon $920,642 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular mechanisms of DNA breathing fluctuations and their roles in the assembly, function, and control of macromolecular complexes that direct DNA replication in bacteriophage T4. The award funds research conducted by the collaborative groups of Professors Andrew H. Marcus and Peter...
The National Institute of Biomedical Imaging and Bioengineering awarded $579,935 to the University of Oregon on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a synthetic biology toolkit for use in animal models. The recipient will create a comprehensive platform for synthetic biology using the nematode Caenorhabditis elegans, including a flexible toolbox of synthetic zinc finger and dCas9-derived transcription factors controlled by non-native chemical inducers and linked through synthetic and native promoter targets to build complex regulatory circuits. The project will develop a collection of synthetic C. elegans promoters with tunable expression control, create Cas9-based circuits for controlling gene expression at native genomic loci, and use these synthetic circuits to precisely regulate embryonic lethal genes. The work addresses age-related decline and disease by enabling precise probing of cellular function in an intact animal model, circumventing the co-dependencies of natural systems to generate novel phenotypic outcomes that inform clinical research. Performance occurs at the University of Oregon in Eugene, Oregon. The period of performance runs from September 1, 2026, through August 31, 2027. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $579.9k | 8/14/26 |