Project Grant R21EB039863
- The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $731,646 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to design synthetic luciferase–substrate pairs for bioluminescent bioimaging and biosensing. The project, titled "Designing Biological Light from Scratch: A New Paradigm for Bioimaging and Biosensing," combines de novo protein design, synthetic chemistry, and deep learning to engineer...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $582,137 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop electrochemical aptamer-based sensors for long-duration, real-time molecular measurements in living tissue. The research aims to extend the in vivo operational lifespan of electrochemical aptamer-based sensors beyond their...
- Federal Grant Award Summary The University of California Santa Cruz received a $412,276 Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded September 1, 2025, with completion targeted for August 31, 2027. This award supports the development and validation of an optofluidic biosensor integrating a waveguide spectrometer for spectral...
- The National Institutes of Health Office of the Director awarded the University of California Santa Cruz $714,870 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop bifunctional small molecules for biosensing and continuous enzyme evolution. The project addresses two bottlenecks in directed enzyme evolution: the low throughput of classical analytical methods, which explore only 10² variants per round, and the labor-intensive manual operations between...
- The National Institutes of Health Office of the Director awarded $672,000 to the University of California, San Diego on August 24, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop synthetic uniRFP-based biosensors (SUBs) for real-time detection of small molecules in living systems. The award funds creation of an experimental platform and predictive machine learning algorithm that engineers the binding pocket of UNAG, a naturally occurring eel fluorescent protein, to...
- The National Institute of General Medical Sciences awarded $430,109 to The Regents of the University of California, operating Lawrence Berkeley National Laboratory, on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop deeply subwavelength near infrared imaging technology using avalanching nanoparticles. The project addresses fundamental limitations of live-cell optical microscopy by creating avalanching nanoparticles (ANPs) that upconvert incident...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Santa Barbara $1,189,496 on April 10, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop real-time, seconds-resolved measurements of amino acid homeostasis using electrochemical aptamer-based (EAB) sensors. The project will adapt EAB sensor technology—a platform invented by UCSB researchers—to measure plasma...
- The National Institute of Biomedical Imaging and Bioengineering awarded Scripps Research Institute $276,000 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate novel fluorescence resonance energy transfer (FRET) sensing methods that leverage entangled photons for biomedical applications. The project will explore quantum sensing technologies to advance FRET-based detection across biological...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Trustees of Princeton University $597,419 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop scalable and deployable multiplexed nucleic acid detection using CRISPR-based Cas13 technology. The research combines miniaturized CRISPR-based nucleic acid detection with microfluidic systems to enable highly multiplexed pathogen,...
- The National Institute of General Medical Sciences awarded $124,767 to The Regents of the University of California, San Francisco on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance de novo protein design for catalysis and fluorescence imaging. The research tests the hypothesis that protein dynamics, particularly enrichment of productive conformations, contribute to enhanced catalytic rates in engineered proteins. Prior work under this funding...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of California Santa Cruz $234,750 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a de novo binder-luciferase platform for multiplexed protein detection in Western blots and lateral flow assays. The project will replace antibody-based detection reagents with computationally designed, thermostable de novo protein binders integrated with next-generation designer luciferase into single-chain probes. The platform will enable binding and signal generation within individual modules with robust folding and high-yield expression in E. coli, supporting plug-and-play retargeting to clinically relevant biomarkers and ambient-temperature deployment at the point of care. The recipient will demonstrate detection of G protein-coupled receptors, intrinsically disordered proteins, and PD-L1 immune checkpoint protein in multiplexed Western blots, and will adapt the platform for multiplexed lateral flow assays targeting SARS-CoV-2 RBD, snake venom toxins, and helical peptide hormones. Spectrally distinct polymer nanoparticle conjugates will provide multi-channel readouts. Performance occurs at Santa Cruz, California, with a period of performance from August 1, 2026, through July 31, 2029. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $234.8k | 7/29/26 |