Project Grant R21OD042639
- The National Institute of General Medical Sciences (NIGMS) awarded a $398,774 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to North Carolina State University. The project aims to develop a microinjection-free approach for genetic manipulation in the model organism Caenorhabditis elegans (C. elegans) by enabling efficient delivery of RNA molecules as single-guide RNAs for CRISPR/Cas systems. The research will involve 1) studying RNA uptake mechanisms in different C....
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $2,001,691 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop PURGE, a computational toolkit for prioritizing guide RNAs in CRISPR epigenome editing applications. The research addresses a fundamental limitation in CRISPR-based epigenome editing: only 10–20 percent of guide RNAs targeting distal regulatory elements successfully...
- The National Institute of Biomedical Imaging and Bioengineering awarded University of California, Berkeley $120,394 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop genome editing delivery vehicles that amplify editing efficiency by enabling cells to produce and distribute CRISPR-Cas9 editing enzymes to neighboring cells in vesicles. The research addresses inefficient delivery of genome editing to cell...
- The federal Project Grant award, titled "ENHANCEMENT OF GENOME EDITING IN HEMATOPOIETIC STEM CELLS BY NUCLEIC ACIDS NANOPARTICLES DELIVERY OF CRISPR/CAS SYSTEM", was granted by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The $486,291 award, effective February 1, 2025 through January 31, 2028, supports the development of a nucleic acid nanoparticle technology to efficiently deliver the CRISPR/Cas9 system into...
- The National Institute of Child Health and Human Development awarded University of Massachusetts Medical School $460,625 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop humanized muscle xenograft models for optimizing and assessing genome editing therapeutics targeting limb-girdle muscular dystrophy R9 (LGMDR9). The project delivers two specific research aims. Aim 1 optimizes prime editing correction of the FKRP L276I mutation in...
- The National Heart, Lung, and Blood Institute awarded the Regents of the University of Michigan $167,400 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop nanoparticle-mediated delivery of CRISPR-Cas9 gene editing for sickle cell disease treatment. The project focuses on advancing non-viral platforms for therapeutic gene editing of hematopoietic stem and progenitor cells. Current gene therapy approaches using ex vivo viral transduction or...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $100,000 will support research to develop next-generation clustered regularly interspaced short palindromic repeat (CRISPR) systems for curing inherited diseases. Specifically, the awardee, the University of California, Berkeley, will work to circumvent in vivo delivery challenges with CRISPR-Cas9 by developing miniature RNA-guided genome editors smaller than Cas9 that can be...
- Federal Project Grant Award Summary The University of Massachusetts Medical School (UMMS) received a $1.1 million CAREER award from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) to support fundamental research on novel bacterial immune systems for genome editing applications. Awarded August 1, 2025, with a completion date of July 31, 2030, this project will deliver scientific research outputs including...
- The National Institute of General Medical Sciences awarded The Regents of the University of California (UC Riverside) $420,520 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of CRISPR-Cas9 genome editing using molecular simulations and AI-driven approaches. The research integrates physics-based molecular simulations with artificial intelligence methods to advance understanding of CRISPR-Cas9 conformational dynamics,...
- The National Institute of Environmental Health Sciences awarded The Broad Institute, Inc. $387,000 on August 1, 2026, under the Medical Library Assistance program (CFDA 93.879) to develop bioinformatics and computational methods for integrative structure-function analysis of CRISPR base-editor tiling mutagenesis experiments. The project will create scalable bioinformatics pipelines to link base-editor library data and screening results to protein sequence-structure-function relationships,...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop lipid nanoparticle technology for simplified CRISPR/CAS9 gene editing in Caenorhabditis elegans nematodes. The funded work addresses a bottleneck in C. elegans research where microinjection of CRISPR guides limits throughput for genome-wide mutagenesis studies. The project repurposes lipid nanoparticle technology to deliver genome editing reagents without microinjection, enabling high-throughput targeted mutagenesis and functional testing of hypotheses from omics-level sequencing. This approach will eliminate the need for specialized microinjection equipment and training currently required in C. elegans research labs. Performance runs from August 1, 2026, through July 31, 2028, at the University of Massachusetts Medical School in Worcester, Massachusetts. The award is classified as a Project Grant, an assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 7/20/26 |