This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345.00 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility in diabetes. The goal is to investigate how impaired...
This Project Grant award, valued at $128,286, was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of the project is to uncover the underlying cellular mechanisms that contribute to the effects of free fatty acid-induced lipotoxicity in kidney tubular epithelial cells and the development of chronic kidney disease (CKD). The research will be conducted at The...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the molecular and genetic mechanisms underlying ischemic acute kidney injury (AKI). The $117,000 award, with a performance period from August 2024 to July 2026, will investigate the hypothesis that the transcription factor PAX8 controls sensitivity to...
This Project Grant award of $117,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support a research project conducted by the Regents of the University of Michigan to identify gene regulatory networks related to hypoxia inducible factor-1A (HIF1A) in the kidney cortex and medulla. The project aims to use multiome data to validate predicted transcription factor motifs in areas of open...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to elucidate the effect of activating branched-chain amino acid (BCAA) catabolism in treating acute kidney injury (AKI) and the transition to fibrosis. The $155,562 award, effective December 11, 2025 through June 30, 2026, will fund comparative single-cell RNA sequencing and phospho-proteomics analyses in...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award, valued at $450,000.00 and awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the roles of the lysine acetyltransferase KAT8 in adipocyte function and its impact on lipoatrophy and systemic insulin resistance. The long-term objective is to understand how adipocyte KAT8 contributes to adipose tissue function and...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This Project Grant award, valued at $400,000 and awarded on September 5, 2024, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research conducted by the University of Mississippi Medical Center to investigate the role of insulin resistance in the development of renal disease during prepubertal childhood obesity, in the absence of diabetes....