The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,428,186 Project Grant under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA. The grant, effective January 1, 2025 through December 31, 2029, will fund research to biochemically characterize N-acyl amino acids as substrates and competitive inhibitors of CYP4F enzymes, define the functional consequences of N-acyl...
This $511,336 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to determine the mechanisms, therapeutic potential, and regulation of a liver-specific mitochondrial carrier protein called SLC25A47. The research aims to understand how inhibiting SLC25A47 can limit...
This $806,452 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research investigating the mechanisms that combine type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The research aims to determine how hepatic insulin resistance can lead to the progression of NAFLD to the more severe non-alcoholic steatohepatitis (NASH), and how this...
This Project Grant award, valued at $128,286, was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of the project is to uncover the underlying cellular mechanisms that contribute to the effects of free fatty acid-induced lipotoxicity in kidney tubular epithelial cells and the development of chronic kidney disease (CKD). The research will be conducted at The...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the carbohydrate responsive element binding protein (ChREBP) and its isoforms in liver metabolism, metabolic diseases, and associated steatohepatitis. The $626,429 award, effective from July 1, 2025 to May 31, 2030, will employ genetic interventions...
This federal Project Grant award of $1,618,520.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to define the molecular and physiological mechanisms of a novel lysosomal lipolysis pathway in adipocytes. The principal objectives are to: 1) Elucidate the molecular and cell biological mechanisms governing fatty acid mobilization from adipocytes during fasting via lysosomal...
This $409,375 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at The Johns Hopkins University to understand the contribution of hepatic fatty acid oxidation to hepatic and systemic metabolic homeostasis. The research aims to describe novel requirements and signaling roles of hepatic fatty acid oxidation that...
This federal Project Grant award of $640,001.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, which runs from January 1, 2025 to November 30, 2028, supports research conducted by Yale University to explore the mechanisms by which the protein polycystin-1 (PC1) and its C-terminal fragments affect mitochondrial function and cellular energy...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This federal Project Grant award of $646,070.00 was awarded on September 15, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary awardee is Rockefeller University, a private research university in New York City. The grant will fund research to investigate the physiological and molecular functions of choline transport in mammals, focusing on the role of the...