This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $581,737.00 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the role of red blood cell (RBC) trapping in mediating kidney injury following ischemia. The key research objectives are to: 1) Investigate how RBC trapping...
This federal Project Grant award of $830,500.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to investigate the role of glycosphingolipids in the development and progression of kidney disease in obesity and diabetes. The award, effective January 20, 2025 through November 30, 2028, will fund studies conducted by Georgetown University to test hypotheses that...
This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
This Project Grant award of $532,177 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate a new inflammation pathway in diabetic kidney disease (DKD). The University of North Texas Health Science Center at Fort Worth will conduct in vitro and in vivo studies to: 1) determine how the transcription modulator I-MFA stimulates inflammatory cytokine production in...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $548,830 to Nephsmart LLC to develop and test a point-of-care device that can detect extensive cleavage of a specific protein in the urine, which preliminary data suggests can predict the future development of severe acute kidney injury (AKI). The goal is to create a test that can differentiate between...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...
This federal Project Grant award of $579,097 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to The University of Texas MD Anderson Cancer Center. The funding supports research focused on understanding the role of mitochondrial electron transport chain (ETC) dysfunction in the development and progression of diabetic kidney disease (DKD). The research aims to identify novel regulatory...
This Project Grant award of $117,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support a research project conducted by the Regents of the University of Michigan to identify gene regulatory networks related to hypoxia inducible factor-1A (HIF1A) in the kidney cortex and medulla. The project aims to use multiome data to validate predicted transcription factor motifs in areas of open...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $133,500 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Boston Medical Center Corporation (BMC) with a start date of September 1, 2024 and end date of August 31, 2026. The grant will fund research on the relationship between APOL1 genotypes and biomarkers of immune activation and tubular injury in the context of chronic kidney disease (CKD) in sub-Saharan...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345.00 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility in diabetes. The goal is to investigate how impaired autophagy and heightened endoplasmic reticulum stress contribute to tubular hypertrophy and exacerbate AKI severity in diabetic patients. The research is expected to run from May 1, 2025 through March 31, 2029 and aims to identify novel therapeutic targets for preventing and treating AKI in diabetic individuals, ultimately improving clinical outcomes and reducing mortality rates.