This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $820,119 to The Washington University to conduct research on mechanisms related to chronic kidney diseases, with a focus on glomerular diseases. The goal is to better understand the pathogenesis of glomerular diseases and identify potential therapeutic targets to improve outcomes for...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $424,278 to The University of Texas Southwestern Medical Center to elucidate novel mechanisms underlying the pathogenesis of Alport syndrome. Alport syndrome is a hereditary chronic kidney disease, and this research aims to identify the specific contributions of glomerular and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $246,000 Project Grant (R21) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of California, San Francisco (UCSF). The purpose of this 2-year project is to develop novel genetic tools to enable the study of type IV collagens, which are critical components of the extracellular matrix involved in genetic and acquired kidney diseases....
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $164,040 project grant (Grant ID K08DK136914) to the University of Pittsburgh under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to clarify the role of the unfolded protein response (UPR) pathway and the PERK stress sensor in acute kidney injury (AKI) using a novel mouse model. The research seeks to discern the mechanism by which PERK drives AKI...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $400,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Mississippi Medical Center (UMMC). The project aims to investigate the role of insulin resistance in the development of renal disease during prepubertal childhood obesity, which has emerged as a significant public health issue. Specifically, the research will explore how...
This federal Project Grant award of $1,100,789 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to elucidate critical signaling pathways that disrupt podocyte cytoarchitecture in order to identify targets for therapeutic intervention for glomerular diseases.
The key objectives are to: 1) define the regulators of WWC1/KIBRA expression and function in podocytes, 2)...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $238,184 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant will fund the development of an easy-to-use, modular 3D in vitro model of the developing nephron that enables spatial patterning of extracellular matrix, stromal cells, and soluble factors. The goal is to provide researchers without microfluidic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to establish robust phenotyping pipelines for early detection of Collagen Type IV-Associated Nephropathy (COL4A-AN) using electronic health records (EHR) data. The $166,643 award to the Trustees of Columbia University seeks to leverage natural language processing (NLP) and standardized...
The federal Project Grant award R03DK138962, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify gene regulatory networks related to hypoxia inducible factor-1a (HIF1a) in the kidney cortex and medulla. The $117,000 award will be used to validate predicted transcription factor binding motifs, generate multiome data to map gene...
This $700,619 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to study and control rhythmic nephron formation for the development of functional kidney replacement tissues.
The research objectives are to: 1) determine the coordination of pace-making mechanisms across cell types in the mouse nephrogenic niche, and 2) synthetically engineer...