This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $243,590 to the University of Chicago to study the role of the mitophagy receptor BNIP3 in regulating lipid homeostasis in the liver. The goal is to define the mechanisms by which BNIP3 decreases lipid droplet content through promoting mitophagy and lipophagy, particularly in the...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,428,186.00 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to conduct research on the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans. The project aims to biochemically characterize N-acyl amino acids as substrates and inhibitors of CYP4F...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $938,470 to the University of Massachusetts Medical School to investigate a novel adipokine that may resolve non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in mouse models. The award period runs from September 1, 2024 to June 30, 2028. The research aims...
This $391,250 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on extracellular vesicle-dependent RNA signaling in metabolism. The project aims to identify key proteins involved in the delivery of adipose microRNAs into liver cells via extracellular vesicles, and to determine if this RNA delivery mechanism is necessary for...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $603,632.00 to The Johns Hopkins University to conduct research on the role of the PLA2G12B protein in the assembly and metabolism of triglyceride-rich apolipoprotein B-containing lipoproteins. The research aims to elucidate the mechanisms by which PLA2G12B channels triglycerides into...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $124,536 to investigate the role of branched-chain amino acid (BCAA) metabolism in regulating adiposity during systemic hypoxia. The research aims to elucidate the mechanisms underlying the reprogramming of BCAA metabolism in adipose tissue under oxygen deprivation, and to determine the...
This Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund a $506,598.00 research project at the Harvard T.H. Chan School of Public Health from September 15, 2024 to August 31, 2025. The project aims to determine the effects of dietary fat and carbohydrate composition on fundamental energy metabolism processes, including tissue fuel selection,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,618,520.00 to the University of Pittsburgh to conduct research on a novel lysosomal mechanism of adipocyte lipolysis. The project aims to define the molecular and cell biological mechanisms governing mobilization of fatty acids from adipocytes during fasting, as well as the role of the lysosomal...
This federal Project Grant award of $824,655 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at the University of Illinois to investigate the molecular and regulatory mechanisms by which growth hormone and sex-dependent transcription factors protect the liver from metabolic dysfunction-associated steatotic liver disease...