Project Grant R01DK141752

Award Date 7/1/25
Completion Date 4/30/30
Dollars Obligated $825K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60612, USA
Similar Awards
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the carbohydrate responsive element binding protein (ChREBP) and its isoforms in liver metabolism, metabolic diseases, and associated steatohepatitis. The $626,429 award, effective from July 1, 2025 to May 31, 2030, will employ genetic interventions...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,600,000.00 to the Icahn School of Medicine at Mount Sinai over a period from August 15, 2024 to May 31, 2029. The primary goal of this research project is to discover new "mammokines" - secretory factors from mammary duct luminal cells that may have vital roles in paracrine...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), will support research to elucidate the functional role of non-coding genetic variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The $146,570 award, with a project period from January 1, 2025 to November 30, 2029, will be administered by The Trustees of the University of...
This Project Grant award of $659,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate a novel pathway by which hepatocyte-derived GDF15 improves obesity-associated insulin resistance independent of body weight loss and GDF15 receptor signaling. The research aims to characterize the structural basis and functional consequences of GDF15...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at the Pennington Biomedical Research Center to examine the role of the mitochondrial protein SLC25A25 in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)....
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $243,590 to the University of Chicago to investigate the role of the protein BNIP3 in regulating lipid homeostasis in the liver. The goal is to define the mechanisms by which BNIP3 influences the accumulation of lipid droplets, which is a key factor in the development of non-alcoholic...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $272,964 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The award, effective August 1, 2024 through May 31, 2026, will support research to investigate the role of SMAD1/5/8 signaling in hepatocytes and hepatic stellate cells (HSCs) in liver fibrosis. The...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to characterize survivorship phenotypes and outcomes of liver transplant recipients. The PI will use longitudinal monitoring of patient-reported and clinical data to identify at-risk survivors who may benefit from a navigator-based intervention. The $365,378 award, effective from March 3, 2025 through...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,558,188 supports research to investigate how changes in transcription factor and heterochromatin states impact hepatocyte development, homeostasis, and regeneration in mouse embryos and adult livers. The research, led by investigators at the University of Pennsylvania and Children's Hospital of Philadelphia,...

This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to understand the mechanisms by which growth hormone (GH) and associated signaling pathways, particularly STAT5, confer protection against metabolic dysfunction-associated steatotic liver disease (MASLD) in females compared to males. The $824,655 award, spanning July 2025 to April 2030, will be used by the University of Illinois to: 1) elucidate how female-biased liver transcription factors interact with GH/STAT5 signaling to sustain female-specific gene expression and protect against steatosis, and 2) determine how persistent hepatocyte STAT5 activity alters cell-cell communication within the liver to slow MASLD progression. This research aims to shift current paradigms on hormonal control of sex differences in liver disease, with the potential to uncover new therapeutic strategies and targets for this leading cause of liver failure.

Generated 7/15/25, 5:08 AM