The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $506,598 Project Grant (Award # R56DK140139) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Harvard College President & Fellows Of Harvard T.H. Chan School of Public Health. The award will fund a research project titled "Fluxomics Studies of the Effect of Diet Composition on Energy Metabolism," with an initial performance period from Sep 15, 2024 to Aug 31, 2025. The research aims to determine the effects of dietary fat and carbohydrate content on key metabolic processes underlying energy expenditure and energy excretion, with the goal of better understanding the physiological mechanisms by which diet composition affects body weight. The study will leverage the institution's expertise in fluxomics, an interdisciplinary approach integrating isotope tracer infusion, mass spectrometry, and mathematical modeling to quantify metabolic fluxes. By providing previously unavailable metabolic flux data, the research seeks to reveal the specific processes underlying the changes in energy metabolism observed on different diets, supporting the development of more effective obesity prevention and treatment strategies.
Generated 1/28/25, 10:41 AM