Project Grant R56DE033716

Award Date 5/8/25
Completion Date 5/7/26
Dollars Obligated $481K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Iowa City, IA 52242, USA
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  1. Determine the expression pattern of IRX1 during embryonic development and in adult oral tissue progenitor cell niches.
  2. Identify the role of IRX1 in oral tissues using inducible Cre lineage tracing models.
  3. Analyze the effects of oral wound healing regulated by IRX1.

This research aims to elucidate the genetic and molecular mechanisms underlying the rapid and scarless wound healing capabilities of the oral mucosa, which could lead to improved treatments for oral diseases, chronic wounds, and scarring. The grant period runs from May 8, 2025 to May 7, 2026.

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