This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $249,000.00 to Iowa State University of Science and Technology to conduct research on the mechanism and impact of streptococcal radical-S-adenosylmethionine ribosomally synthesized and post-translationally modified peptides (RAS-RIPPs) on the human oral microbiome. The key objectives are to elucidate the mechanism of action of the RAS-RIPP compound tryglysin from Streptococcus mutans and examine its effects on the functional oral microbiome. The study will then be expanded to investigate the biological significance of other RAS-RIPPs produced by oral streptococci. This research aims to establish a platform for studying RAS-RIPPs from oral streptococci and their impacts on overall oral health. The award period is from August 16, 2024 to August 15, 2027.
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