Project Grant R21AG095696
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- This federal Project Grant award of $145,566 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting research at the Icahn School of Medicine at Mount Sinai to investigate how the brain accumulates and utilizes "cognitive maps" - internal neural representations that enable flexible behavior and memory recall. The research aims to provide insights into the neuronal coding deficits underlying cognitive decline, with the goal of informing therapeutic...
- This $999,975.63 federal Project Grant, awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research by the Icahn School of Medicine at Mount Sinai to investigate the molecular mechanisms behind the increased vulnerability of the APOE4 gene to Alzheimer's disease and identify potential new therapeutic targets. The award period runs from April 1, 2025, to March 31, 2028. The Icahn School of Medicine at Mount Sinai is a leading...
- This Project Grant award, valued at $2,129,396.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award aims to develop and validate engineered adeno-associated viruses (AAVs) that can selectively knock down the follicle-stimulating hormone receptor (FSHR) in neurons within brain regions vulnerable to Alzheimer's disease. This research seeks to understand the role of FSH signaling in cognitive decline and Alzheimer's...
- This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $461,313 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Yale University. The funding supports a 2-year research project to investigate the role of the protein CSPalpha in regulating presynaptic autophagy and neurodegeneration. Key objectives include characterizing synaptic vesicles and autophagosomes in wild-type and CSPalpha knockout mouse models, as well...
- The Icahn School of Medicine at Mount Sinai received a $3,548,990 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the influence of stress on the expression of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) mouse models. The goal is to test the hypothesis that promoting stress resilience could prevent or delay the emergence of AD-associated NPS. The 4-year project, starting on Sep 1, 2025, will examine how stress susceptibility...
- This Project Grant award of $132,472 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the regulation of apoptotic sensitivity, or programmed cell death, in the brain during normal aging and in Alzheimer's disease. The principal investigator, Dr. Zintis Inde, will use functional methods, induced pluripotent stem cells, viral vectors, and flow cytometry to quantify changes in apoptotic priming across different cell types in the normal and Alzheimer's model...
- This $491,163.00 Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research conducted by the Icahn School of Medicine at Mount Sinai focused on understanding the role of plasma membrane properties and cytoskeleton mechanics in regulating neuroprogenitor cell differentiation and neurogenesis during...
- The Icahn School of Medicine at Mount Sinai received a $307,801 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to develop and implement the Postbaccalaureate Alzheimer's Disease Development Initiative (PADDI), a two-year program to train postbaccalaureate students about Alzheimer's disease and related dementia research methodologies and the ethical conduct of research. The program aims to address a lack of ethnic and racial diversity among...
This federal Project Grant award of $463,916.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai. The funding will support a 2-year research project to identify a novel cytoplasmic activation platform for the caspase-2 enzyme, referred to as the "Ankosome", which may play a role in neuronal cell death in Alzheimer's disease. The project aims to elucidate the molecular mechanism by which cytoskeletal injury triggers the assembly of this Ankosome complex, which involves the cytoskeletal adaptor protein Ankyrin-G substituting for PIDD1 as a scaffold. The research will employ genetic screening and structure/function analyses to characterize the Ankosome and its role in caspase-2 activation. This work builds on the institution's prior expertise in studying caspase activation platforms and could lead to a better understanding of Alzheimer's disease pathogenesis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.9k | 8/25/25 |