Project Grant RF1NS147363
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $670,266 on January 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to map the epigenomic and spatial transcriptomic landscape in Parkinson's disease and Alzheimer's disease. The project characterizes shared and distinct transcriptional changes between Parkinson's disease, Alzheimer's disease, and Alzheimer's...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $230,388 on March 4, 2026, under the Aging Research program (CFDA 93.866) to dissect the role of the PICALM/EED locus on myeloid cells in Alzheimer's disease. The recipient will conduct research to understand how an Alzheimer's disease risk enhancer on chromosome 11 influences expression of two target genes—PICALM (phosphatidylinositol binding clathrin assembly protein) and EED (embryonic ectoderm development)—and to...
- The National Institute of Neurological Disorders and Stroke awarded $574,660 to Icahn School of Medicine at Mount Sinai on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neutrophil extracellular trap mitigation in ischemic stroke outcomes. The research addresses vascular contributions to cognitive impairment and dementia following acute ischemic stroke by examining how neutrophils form extracellular...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $462,000 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a novel spatial transcriptomics platform and investigate RNA-binding protein function in human neurons as it relates to schizophrenia risk. The award funds two primary aims. The first develops a spatial RNA-protein interactome MERFISH (SPRIM) platform to visualize endogenous RNA-protein interactions at...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $746,063 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate amyloid beta plaque formation and neuroinflammation in aging people with HIV. The award funds exploration of cell-specific transcriptional changes associated with early amyloid beta deposition in human brain, distinguishing compacted amyloid with early neuritic pathology from diffuse amyloid without neuritic change, and...
- The National Institute of Neurological Disorders and Stroke, an operating division of the National Institutes of Health under the Department of Health and Human Services, awarded $646,706 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop and validate magnetic resonance elastography and arterial spin labeling as novel complementary...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $667,738 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of dentate spikes in cognition and epilepsy. The research uses in vivo electrophysiology with silicon probes to characterize neural activity synchronization across the medial entorhinal cortex and hippocampus during type 2 dentate...
- The National Institute on Aging awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $454,937 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the regulatory landscape of neurodegeneration using single-cell spatial multiomics approaches. The research integrates chromatin accessibility and protein-level measurements to characterize how cells near Alzheimer's disease hallmarks—amyloid-beta and tau—regulate...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $2,129,396 under the Aging Research program (CFDA 93.866) on August 1, 2025, with completion targeted for July 31, 2027. This research grant supports the development and validation of novel adeno-associated virus (AAV) constructs designed to enable gene knockdown in follicle-stimulating hormone receptor (FSHR)-positive neurons within Alzheimer's...
The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $1,967,309 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the role of small non-coding RNAs in microglia-driven neuroinflammation in Alzheimer's disease. The funded research will elucidate how small non-coding RNAs—including microRNA isoforms, transfer RNA-derived fragments, ribosomal RNA-derived fragments, and Y RNA-derived fragments—regulate gene expression and inflammation in microglia, the brain's resident immune cells. The project will generate two complementary atlases of regulator-effector interactions: a bulk-tissue atlas and a high-resolution, cell-type-specific atlas of microglia prospectively isolated from human brain tissue collected postmortem from the prefrontal cortex. These resources will reveal shared and microglia-specific regulatory mechanisms that drive Alzheimer's disease progression and inform mechanisms by which disruption of small RNA networks contributes to disease pathogenesis and modulation of tau and amyloid precursor proteins. Performance occurs at the Icahn School of Medicine at Mount Sinai in New York, New York. The project runs through August 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 8/28/26 |