Project Grant RF1AG096837
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $1,679,866 to Icahn School of Medicine at Mount Sinai, effective September 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This grant funds a research initiative titled "Role of M6A RNA Modifications in Microglial Dysfunction and Alzheimer's Disease Pathogenesis." The project will systematically investigate N6-methyladenosine (M6A) RNA modifications in...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $2,129,396 under the Aging Research program (CFDA 93.866) on August 1, 2025, with completion targeted for July 31, 2027. This research grant supports the development and validation of novel adeno-associated virus (AAV) constructs designed to enable gene knockdown in follicle-stimulating hormone receptor (FSHR)-positive neurons within Alzheimer's...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a $8.07 million Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2030. This research project examines unique markers and risk factors for Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) in foreign- and native-born older Chinese Americans, with particular focus on social determinants of...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Weill Medical College of Cornell University a Project Grant totaling $711,898 under the Aging Research program (CFDA 93.866) for the period September 30, 2025 through June 30, 2030. The research initiative investigates the mechanistic relationship between Apolipoprotein E4 (APOE4), a primary genetic risk factor for Alzheimer's disease, and microglial neuroinflammation mediated by cholesterol 25-hydroxylase (CH25H). The...
- Federal Grant Award Summary The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai a $3.55 million Project Grant under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2029. The grant supports research investigating the relationship between individual vulnerability to stress and the development of neuropsychiatric symptoms (NPS) associated with Alzheimer's Disease (AD). The primary research deliverable involves studying how...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $2,557,950 to The Feinstein Institutes for Medical Research under the Aging Research program (CFDA 93.866) on May 15, 2026, for research investigating the role of neurotoxic astrocytes in Alzheimer's disease (AD) pathogenesis. This R01 Project Grant, which extends through April 30, 2030, focuses on elucidating a novel molecular mechanism whereby extracellular cold-inducible RNA-binding protein (ECIRP) induces...
- Federal Grant Award Summary The J. David Gladstone Institutes received a $1,602,386 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on February 15, 2026, with a project completion date of January 31, 2031. This research initiative, titled "Understanding APOE4-Induced Metabolic Shifts in Alzheimer's Disease," investigates how the APOE4 allele—the strongest genetic risk factor for late-onset Alzheimer's disease—disrupts brain...
- Federal Project Grant Award Summary The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai a $1.2M Project Grant (CFDA 93.866 - Aging Research) commencing February 15, 2026 and concluding November 30, 2030 to conduct research investigating the association between Autism Spectrum Disorder (ASD) and early-onset Alzheimer's Disease and Related Dementias (ADRD). The research project will leverage multiple national health registries—including Swedish National Health...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $463,916 under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award funds research to identify and characterize the "ankosome," a newly discovered cytoplasmic activation platform for caspase-2 (C2) that assembles in response to cytoskeletal injury. This exploratory research (R21 mechanism)...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded New York University School of Medicine a $6.2 million Project Grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct multidisciplinary research examining the relationship between peripheral immune markers and vascular contributions to cognitive decline and dementia. The research integrates biofluid biomarkers—specifically platelet aggregation, neutrophil activity, and proteomic data—with...
The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a $2,944,007 Project Grant effective June 1, 2026 through May 31, 2030, under the Aging Research program (CFDA 93.866). This research project investigates the systemic roles of apolipoprotein E (APOE) genotypes on central nervous system (CNS) health and Alzheimer's disease (AD) pathobiology. The research deliverables include scientific studies examining how blood-borne factors and the systemic environment differentially influence brain function and AD pathology based on APOE genotype variants. The project employs experimental models including plasma transfer and parabiosis studies to characterize neuroimmunological communication mechanisms between the periphery and CNS, with particular focus on identifying APOE4-associated and APOE3-associated mediators that regulate hippocampal-dependent behavioral and cognitive outcomes in both healthy aging and AD contexts. The research outputs are designed to advance understanding of the relationship between common genetic risk factors for AD and underlying pathomechanisms, with potential implications for identifying novel therapeutic targets within the systemic environment. This work supports the NIA's mission to promote biomedical research directed toward understanding aging processes and age-related diseases, particularly Alzheimer's disease and related dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.9m | 6/3/26 |