Project Grant R56AG090904
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- The National Institute on Aging awarded the University of California, San Diego $408,012 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop methods for improving central nervous system pharmacokinetics of targeted protein degraders through specialized assay workflows and prodrug chemistries. The research will establish dual-functional molecules that hijack endogenous molecular transport pathways to cross the blood-brain barrier, with early-stage application to...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $663,237 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support multiscale structural approaches defining tau filaments and cellular dysfunction associated with Alzheimer's disease and related dementias (ADRDs). The research integrates histological and structural imaging methods with cryo-electron microscopy to characterize tau fibril structures, aggregate morphologies, and...
- The National Institute on Aging awarded the University of California, Los Angeles $126,063 on August 5, 2026, under the Aging Research program (CFDA 93.866) to determine the atomic structures of amyloid-beta and tau oligomers and to characterize the molecular interaction between amyloid-beta and the TREM2 receptor on microglia. The award is classified as a Project Grant, specifically a K99/R00 award. The research develops a novel oligomer structure determination pipeline incorporating native...
- The National Institute on Aging awarded the Scripps Research Institute $2.613 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate a druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in aging and Alzheimer's disease. The research focuses on elucidating how age and pathological tau destabilize a brain-specific mito-nuclear feedback loop that controls mitochondrial gene expression in response to acetyl-CoA...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $681,908 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate protective mechanisms of UFM1-dependent IRE1 signaling in tauopathies, with work performance in San Francisco, California through November 30, 2030. The project addresses tau protein aggregation in Alzheimer's disease and related tauopathies by elucidating molecular mechanisms linking the ufmylation pathway...
- The National Institute on Aging awarded New York University $422,297 under the Aging Research program (CFDA 93.866) on February 15, 2026, to investigate mechanisms of dysregulated protein synthesis in human neurons carrying frontotemporal dementia–associated tau mutations. The project uses human induced pluripotent stem cell–derived neurons bearing FTD-associated tau mutations to model how pathogenic tau disrupts protein synthesis. In the first aim, researchers will determine the impact of...
- The National Institute on Aging awarded Ohio University $567,256 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanisms of activity-dependent tau release in Alzheimer's disease pathogenesis. The research elucidates how neuronal hyperexcitability drives tau release from neurons and synapses, using a Drosophila model and human neural cell lines. Aim 1 investigates activity-dependent tau release from neurons and synapses, focusing on synaptic vesicle...
The National Institute on Aging awarded $423,592 to the University of Southern California on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate neurotransmitters as modulators of tau protein aggregation in Alzheimer's disease. The recipient is conducting structure-based research on monoaminergic neurotransmitters and their concentration-dependent effects on tau seeding, a disease-relevant mechanism by which fibrillar and oligomeric proteins catalyze aggregation. The research integrates cell seeding assays, fibril disaggregation measures, and electron microscopy to determine molecular structures of fibril complexes and the mechanisms by which neurotransmitters and synthetic disaggregases influence tau aggregation. Preliminary data indicate that neurotransmitters and disaggregases actively disaggregate both oligomers and fibrils, potentially preventing accumulation of either molecular species. The work tests the hypothesis that monoaminergic neurotransmitter levels help shape protein aggregation propensity and determine selective cellular vulnerability to aggregation-related disease. Performance occurs in Los Angeles, California with a period of performance from September 1, 2026, through August 31, 2027. The award is categorized as a Project Grant, the standard assistance type for individual research projects under the Aging Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.6k | 8/31/26 |