Project Grant R01AG097702
- The National Institute on Aging awarded $152,600 to Baylor College of Medicine on December 26, 2026, under the Aging Research program (CFDA 93.866) to investigate the synergistic mechanisms of tau and amyloid-beta aggregation in Alzheimer's disease pathology. The project, titled "Synergy in Condensation: Tau and AB in Alzheimer's Disease," employs advanced biophysical techniques including fluorescence lifetime imaging microscopy and microfluidic modulation infrared spectroscopy to...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $663,237 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support multiscale structural approaches defining tau filaments and cellular dysfunction associated with Alzheimer's disease and related dementias (ADRDs). The research integrates histological and structural imaging methods with cryo-electron microscopy to characterize tau fibril structures, aggregate morphologies, and...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $154,960 to the University of Kansas Medical Center Research Institute, Inc. on February 26, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct research combining cellular and clinical measures to examine bioenergetic contributions to tau phosphorylation in aging and Alzheimer's disease. The work leverages existing clinical data from the KU...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded Boston University Medical Campus $110,228 in project grant funding on February 7, 2027, to develop and validate a novel cellular model of entorhinal cortex layer II vulnerability in Alzheimer's disease under the Aging Research program (CFDA 93.866). The project will develop in vitro models using induced pluripotent stem cells (iPSCs) and direct fibroblast conversion to generate entorhinal cortex layer II (ECII)-like neurons for studying Alzheimer's disease...
- The National Institute on Aging awarded $423,592 to the University of Southern California on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate neurotransmitters as modulators of tau protein aggregation in Alzheimer's disease. The recipient is conducting structure-based research on monoaminergic neurotransmitters and their concentration-dependent effects on tau seeding, a disease-relevant mechanism by which fibrillar and oligomeric proteins catalyze aggregation. The...
- The National Institute on Aging awarded the University of Connecticut Health Center $459,322 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular intersection of tau, phosphatases, and Alzheimer's disease. The research identifies how serine/threonine protein phosphatases (PPPs) bind tau and regulate tau phosphorylation status in health and disease. The project leverages nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and...
- The National Institute on Aging awarded Brandeis University $142,997 on October 16, 2025, under the Aging Research program (CFDA 93.866) to investigate associations among monoamines, tau pathology, and emotional memory in aging using positron emission tomography methods. The research uses [18F]fluoro-m-tyrosine ([18F]FMT) and [18F]MK-6240 PET tracers to measure monoamine synthesis capacity in the locus coeruleus and dorsal raphe nucleus—brainstem regions among the first to accumulate abnormal...
- The National Institute on Aging awarded Ohio University $567,256 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanisms of activity-dependent tau release in Alzheimer's disease pathogenesis. The research elucidates how neuronal hyperexcitability drives tau release from neurons and synapses, using a Drosophila model and human neural cell lines. Aim 1 investigates activity-dependent tau release from neurons and synapses, focusing on synaptic vesicle...
- The National Institute on Aging awarded New York University $422,297 under the Aging Research program (CFDA 93.866) on February 15, 2026, to investigate mechanisms of dysregulated protein synthesis in human neurons carrying frontotemporal dementia–associated tau mutations. The project uses human induced pluripotent stem cell–derived neurons bearing FTD-associated tau mutations to model how pathogenic tau disrupts protein synthesis. In the first aim, researchers will determine the impact of...
The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests the hypothesis that post-translational modifications—specifically phosphorylation at serine and threonine residues and acetylation at lysine residues—cause disease-specific dynamics and residual structures of tau's mobile domains that control rigid-core formation, core structure adoption, and aggregate propagation. The investigative approach includes solution nuclear magnetic resonance experiments on monomers and J-coupling based magic-angle-spinning solid-state NMR experiments on fibrils, with particular focus on phospho-mimetic tau and Alzheimer's paired helical filament-seeded tau. Performance of work occurs in Cambridge, Massachusetts. The period of performance runs from the award date through May 31, 2031. This is a Project Grant, the standard assistance type for individual research projects under the National Institute on Aging's mission to support biomedical and behavioral research directed toward understanding the aging process and Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $596.1k | 9/2/26 |