This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $784,596 to Northeastern University to conduct comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The goal is to substantially expand understanding of protein dysfunctions in AD by profiling multiple brain regions, disease stages, and subtypes using advanced mass spectrometry methods. The research will also pair...
This $15,046,454 project grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at the University of California, San Diego to improve understanding of proteomic changes preceding Alzheimer's disease and related dementias. The research will analyze longitudinal plasma samples from 2,836 women in the Women's Health Initiative Memory Study cohort using the Somamscan proteomics platform to identify novel...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $412,751 to The Trustees of Columbia University in the City of New York to study the changes in protein turnover and proteome integrity that occur during physiological brain aging. The key objectives are to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition; (III) reveal which protein interaction states have altered turnover...
The National Institute on Aging (NIA) awarded a $846,358 Project Grant (CFDA 93.866 - Aging Research) to the University of Pittsburgh to build a research platform for assessing the senescence-associated secretory phenotype (SASP) in vivo. The goal is to identify the molecular identity of the SASP secretome across different cell types and in response to various senescence-inducing stimuli. The researchers will utilize a novel SASP-ER platform to conditionally tag and purify secreted proteins from...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) in the amount of $802,034 will fund a multi-year, multi-modal systems biology research infrastructure to advance precision medicine for Alzheimer's disease (AD) and longevity. The award recipient, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, will conduct integrated analyses of diverse datasets, including genetics, multi-omics, cross-species protein...
The National Institute on Aging (CFDA 93.866) awarded a $1,274,993 Project Grant to Epicypher, Inc. to develop a new approach called Reverse Transcribe & Tagmentation (RT & TAG) for identifying chromatin-associated RNAs (CARNAs), including nascent RNA transcripts, to accelerate aging and Alzheimer's disease/age-related dementia (AD/ADRD) research. The central innovation is an immunotethering-based method for in situ targeted tagmentation of CARNAs. The project also involves developing...
The National Institute on Aging (NIA) awarded a $3,070,537 Project Grant under the Aging Research program (CFDA 93.866) to the University of Maryland, College Park (UMD) to develop and validate a new proteomics platform called Scalable Single-Cell Mass Spectrometry (SCEMAS). The goal is to create a high-sensitivity mass spectrometry approach to characterize proteomic changes associated with aging, such as in neurons, neuronal subtypes, and cerebrospinal fluid. The project will leverage invertebrate and vertebrate biological models to advance sample collection, processing, and data acquisition methods to enable integrated electrophysiology and proteomics analysis. This effort brings together a multidisciplinary team to identify proteomic signatures of healthy aging, accelerated aging in progeria, and neurodegenerative diseases, expanding the bioanalytical capabilities for aging research.